(2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester

Base Information

Chemical Name:(2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester
CAS No.:198969-19-6
Molecular Formula:C17H23NO5
Molecular Weight:321.373
Hs Code.:
Mol file:198969-19-6.mol

Synonyms:(2R,4R)-1-Boc-2-Methyl-4-phenoxypyrrolidine-2-carboxylic acid;

Suppliers and Price of (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:411.654°C at 760 mmHg
Flash Point:202.761°C
PSA：76.07000
Density:1.173g/cm³
LogP:2.85600

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester

There total 1 articles about (2R,4R)-4-Phenoxy-1,2-pyrrolidinedicarboxylic acid1-(1,1-dimethylethyl)-2-methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 135042-17-0
(2R,4S)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 108-95-2,27073-41-2
phenol

: 198969-19-6
(2R,4R)-1-tert-butyl 2-methyl 4-phenoxypyrrolidine-1,2-dicarboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm970439a

Reference yield: 85.0%

: 198969-19-6
(2R,4R)-1-tert-butyl 2-methyl 4-phenoxypyrrolidine-1,2-dicarboxylate

: 198968-94-4
(2R,4R)-4-Phenoxy-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1021/jm970439a

Reference yield:

: 198969-19-6
(2R,4R)-1-tert-butyl 2-methyl 4-phenoxypyrrolidine-1,2-dicarboxylate

: (2R,4R)-1-[(R)-2-(Adamantan-2-yloxycarbonylamino)-3-(1H-indol-3-yl)-2-methyl-propionyl]-4-phenoxy-pyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / TFA / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 85 percent / DIEA, BOP / dimethylformamide / 48 h / Ambient temperature

3: 1N aq. NaOH / dioxane / 5 h / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970439a