methyl 5-methylbenzo[d]oxazole-2-carboxylate

Base Information

• Chemical Name: methyl 5-methylbenzo[d]oxazole-2-carboxylate
• CAS No.: 27383-91-1
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.18
• Hs Code.: 2934999090
• Mol file: 27383-91-1.mol

Synonyms:5-methyl-benzooxazole-2-carboxylic acid methyl ester;5-methyl-benzoxazole-2-carboxylic acid methyl ester;methyl 5-methylbenzo[d]oxazole-2-carboxylate;methyl 5-methyl-2-benzoxazolecarboxylate;5-Methylbenzoxazol-2-carbonsaeuremethylester;

Chemical Property of methyl 5-methylbenzo[d]oxazole-2-carboxylate

Chemical Property:

• PSA: 52.33000
• LogP: 1.92280
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-methylbenzo[d]oxazole-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 5-methylbenzo[d]oxazole-2-carboxylate

There total 10 articles about methyl 5-methylbenzo[d]oxazole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.9%

5-methyl-1,3-benzoxazole (10531-78-9) + carbon dioxide (124-38-9,18923-20-1) + methyl iodide (74-88-4) → methyl 5-methylbenzo[d]oxazole-2-carboxylate (27383-91-1)

Guidance literature:

5-methyl-1,3-benzoxazole; carbon dioxide; With Mo₂(O-t-Bu)6; caesium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 10h; under 760.051 Torr; Schlenk technique;

methyl iodide; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Schlenk technique;

DOI:10.1039/c7gc03372a

Reference yield:

5-methyl-1,3-benzoxazole (10531-78-9) → methyl 5-methylbenzo[d]oxazole-2-carboxylate (27383-91-1)

Guidance literature:

Multi-step reaction with 2 steps

1: C₂₇H₃₇ClCuN₃; potassium tert-butylate / tetrahydrofuran / 8 h / 80 °C / 760.05 Torr / Inert atmosphere; sealed tube

2: N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; sealed tube

With C₂₇H₃₇ClCuN₃; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ol301760n

Reference yield:

5-methyl-benzooxazole-2-carboxylic acid (49559-66-2) + methyl iodide (74-88-4) → methyl 5-methylbenzo[d]oxazole-2-carboxylate (27383-91-1)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 1h; Inert atmosphere; sealed tube;

DOI:10.1021/ol301760n

upstream raw materials:

5-methyl-benzooxazole-2-carboximidic acid methyl ester

2-chloro-5-methyl-1,3-benzoxazole

5-methyl-benzooxazole-2-carbonitrile

5-methyl-1,3-benzoxazole