3-phenyl-tetrahydrofuran

Base Information

• Chemical Name: 3-phenyl-tetrahydrofuran
• CAS No.: 16766-63-5
• Molecular Formula: C10H12O
• Molecular Weight: 148.205
• Hs Code.: 2932190090
• Mol file: 16766-63-5.mol

Synonyms:3-phenyloxolane;

Chemical Property of 3-phenyl-tetrahydrofuran

Chemical Property:

• PSA: 9.23000
• LogP: 2.19050

Purity/Quality:

98%min ^*data from raw suppliers

3-Phenyl-tetrahydrofuran >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-phenyl-tetrahydrofuran

There total 13 articles about 3-phenyl-tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-phenyl-2,5-dihydrofuran (15377-93-2) → 5-phenyl-3,4-dihydro-2H-pyran (16766-63-5)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; under 1500.15 Torr;

DOI:10.1002/chem.201104073

Reference yield: 98.0%

(1,4-dimethoxybutan-2-yl)benzene (71053-00-4) → 5-phenyl-3,4-dihydro-2H-pyran (16766-63-5)

Guidance literature:

With 1-methyl-3-(4-sulfonylbutyl)-1H-imidazol-3-ium trifluoromethanesulfonate; at 120 ℃; for 24h; Catalytic behavior; Sealed tube; Inert atmosphere;

DOI:10.1002/anie.202004002

Reference yield: 93.0%

(+/-)-2-phenyl-1,4-butanediol (6837-05-4) → 5-phenyl-3,4-dihydro-2H-pyran (16766-63-5)

Guidance literature:

With p-nitrobenzenesulfonamide; cyanomethylenetributyl-phosphorane; In tetrahydrofuran; toluene; at 80 ℃; for 2.5h; Inert atmosphere;

DOI:10.3987/COM-12-12481

upstream raw materials:

4-phenyl-2,3-dihydrofuran

(+/-)-2-phenyl-1,4-butanediol

3-phenyl-2,5-dihydrofuran

2-phenylsuccinic acid

Downstream raw materials:

(rac)-N-benzyl-3-phenylpyrrolidine

4-chloro-2-phenyl-1-butyl benzoate

4-chloro-3-phenyl-1-butyl benzoate

Refernces

• 1、 Wang, Huan,Zhao, Yanfei,Zhang, Fengtao,Wu, Yunyan,Li, Ruipeng,Xiang, Junfeng,Wang, Zhenpeng,Han, Buxing,Liu, Zhimin. "Hydrogen-Bonding Catalyzed Ring-Closing C?O/C?O Metathesis of Aliphatic Ethers over Ionic Liquid under Metal-Free Conditions". supporting information. p. 11850 - 11855. Retrieved 2020/05/16.
• 2、 Asai, Shota,Kato, Maho,Monguchi, Yasunari,Sajiki, Hironao,Sawama, Yoshinari. "Cyclic ether synthesis from diols using trimethyl phosphate". supporting information. p. 4787 - 4790. Retrieved 2017/07/06.