71053-00-4

Usage

Uses

Used in Pharmaceutical Industry:
(1,4-dimethoxybutan-2-yl)benzene is used as a pharmaceutical agent for its diverse biological activities, including antioxidant and anti-inflammatory properties. These characteristics make it a valuable compound for the development of new drugs and therapies.
Used in Cosmetic Industry:
In the cosmetic industry, (1,4-dimethoxybutan-2-yl)benzene is used as an ingredient for its antioxidant and anti-inflammatory properties, which can contribute to the formulation of skincare products that promote skin health and protection.
Used in Fragrance and Flavoring Compounds Production:
(1,4-dimethoxybutan-2-yl)benzene is used as a component in the production of fragrance and flavoring compounds due to its unique chemical structure and potential aromatic properties, adding to the variety of scents and tastes in various consumer products.

Upstream product

• 55955-55-0 methyl 3-chloro-3-phenylpropyl ether 
• 107-30-2 chloromethyl methyl ether 
• 6837-05-4 (+/-)-2-phenyl-1,4-butanediol 
• 74-88-4 methyl iodide 

Downstream Products

• 16766-63-5 5-phenyl-3,4-dihydro-2H-pyran 
• 115-10-6 Dimethyl ether 
• 118408-32-5 3-phenyltetrahydro-2H-pyran 
• 16133-83-8 tetrahydro-2-phenylfuran 
• 71052-99-8 (3-Bromo-1-bromomethyl-propyl)-cyclohexane 
• 71053-01-5 (3-Methoxy-1-methoxymethyl-propyl)-cyclohexane 

Relevant academic research and scientific papers

Hydrogen-Bonding Catalyzed Ring-Closing C?O/C?O Metathesis of Aliphatic Ethers over Ionic Liquid under Metal-Free Conditions

O-heterocycles have wide applications, and their efficient and green synthesis is very interesting. Herein, we report hydrogen-bonding catalyzed ring-closing metathesis of aliphatic ethers to O-heterocycles over ionic liquid (IL) catalyst under metal- and solvent-free conditions. The IL 1-butylsulfonate-3-methylimidazolium trifluoromethanesulfonate ([SO3H-BMIm][OTf]) is discovered to show outstanding performance, better than the reported catalysts. An interface effect plays an important role in mediating the reaction rate due to the immiscibility between the products and the IL catalyst, and the products can be spontaneously separated. NMR analysis and DFT calculation suggest that a pair of cation and anion of [SO3H-BMIm][OTf] could form three strong H-bonds with an ether molecule, which catalyze the ether transformation via a cyclic oxonium intermediate. A series of O-heterocycles including tetrahydrofurans, tetrahydropyrans, morpholines and dioxane can be obtained from their corresponding ethers in excellent yields (e.g., >99 %). This work opens an efficient and metal-free way to produce O-heterocycles from aliphatic ethers.

Iron-Catalyzed Ring-Closing C?O/C?O Metathesis of Aliphatic Ethers

Among all metathesis reactions known to date in organic chemistry, the metathesis of multiple bonds such as alkenes and alkynes has evolved into one of the most powerful methods to construct molecular complexity. In contrast, metathesis reactions involving single bonds are scarce and far less developed, particularly in the context of synthetically valuable ring-closing reactions. Herein, we report an iron-catalyzed ring-closing metathesis of aliphatic ethers for the synthesis of substituted tetrahydropyrans and tetrahydrofurans, as well as morpholines and polycyclic ethers. This transformation is enabled by a simple iron catalyst and likely proceeds via cyclic oxonium intermediates.