2-Chlorophenylalanine hydrochloride

Base Information

• Chemical Name: 2-Chlorophenylalanine hydrochloride
• CAS No.: 120108-63-6
• Molecular Formula: C9H11Cl2NO2
• Molecular Weight: 236.098
• Mol file: 120108-63-6.mol

Synonyms:2-Chlorophenylalanine hydrochloride

Chemical Property of 2-Chlorophenylalanine hydrochloride

Chemical Property:

• PSA: 63.32000
• LogP: 2.79670

Purity/Quality:

98%Min ^*data from raw suppliers

2-ChlorophenylalanineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chlorophenylalanine hydrochloride

There total 1 articles about 2-Chlorophenylalanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

N-acetyl-3-(2-chlorophenyl)-2-ethoxycarbonyl alanine ethyl ester (5440-50-6) → 2-amino-3-(2-chlorophenyl)propionic acid hydrochloride (120108-63-6,185030-83-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water; Heating;

DOI:10.1016/j.ejmech.2005.01.002

Reference yield: 63.0%

5-fluoroisatoic anhydride (321-69-7) + 2-amino-3-(2-chlorophenyl)propionic acid hydrochloride (120108-63-6,185030-83-5) → 3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (1276544-60-5)

Guidance literature:

5-fluoroisatoic anhydride; 2-amino-3-(2-chlorophenyl)propionic acid hydrochloride; With triethylamine; In water; acetonitrile; at 20 ℃;

With acetic acid; Heating;

Reference yield: 2.0%

6-chloro-1-cyclopropyl-1H-benzo[d][1,3]oxazine-2,4-dione (1251948-97-6) + 2-amino-3-(2-chlorophenyl)propionic acid hydrochloride (120108-63-6,185030-83-5) → 7-chloro-3-(2-chlorobenzyl)-1-cyclopropyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (1251948-98-7)

Guidance literature:

6-chloro-1-cyclopropyl-1H-benzo[d][1,3]oxazine-2,4-dione; 2-amino-3-(2-chlorophenyl)propionic acid hydrochloride; With triethylamine; In water; acetonitrile; at 20 ℃;

With acetic acid; at 130 ℃; for 6h;

upstream raw materials:

N-acetyl-3-(2-chlorophenyl)-2-ethoxycarbonyl alanine ethyl ester

Downstream raw materials:

2-(2-aminobenzoylamino)-3-(2-chlorophenyl)propionic acid ethyl ester

3-(2-chlorophenyl)-2-{2-[(1H-indole-2-carbonyl)amino]benzoylamino}propionic acid ethyl ester

7-chloro-3-(2-chlorobenzyl)-1-cyclopropyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

(E)-5,7-dichloro-3-(2-chlorobenzyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Refernces