3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Base Information

• Chemical Name: 3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
• CAS No.: 1276544-60-5
• Molecular Formula: C₁₆H₁₂ClFN₂O₂
• Molecular Weight: 318.735
• Mol file: 1276544-60-5.mol

Synonyms:3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Chemical Property of 3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

There total 2 articles about 3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

5-fluoroisatoic anhydride (321-69-7) + 2-amino-3-(2-chlorophenyl)propionic acid hydrochloride (120108-63-6,185030-83-5) → 3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (1276544-60-5)

Guidance literature:

5-fluoroisatoic anhydride; 2-amino-3-(2-chlorophenyl)propionic acid hydrochloride; With triethylamine; In water; acetonitrile; at 20 ℃;

With acetic acid; Heating;

Reference yield:

2-amino-5-fluorobenzoic acid (446-08-2) → 3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (1276544-60-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 20 °C

2.1: triethylamine / acetonitrile; water / 20 °C

2.2: Heating

With triethylamine; In tetrahydrofuran; water; acetonitrile;

Reference yield: 71.0%

3-(2-chlorobenzyl)-7-fluoro-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (1276544-60-5) + p-methoxybenzyl chloride (824-94-2) → 3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione (1276544-61-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

2-amino-5-fluorobenzoic acid

5-fluoroisatoic anhydride

2-amino-3-(2-chlorophenyl)propionic acid hydrochloride

Downstream raw materials:

3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione

di-tert-butyl 5-(3-(2-chlorobenzyl)-7-fluoro-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-2-oxo-1H-benzo[d]imidazole-1,3(2H)-dicarboxylate

C₂₄H₁₉Cl₂FN₂O₂

3-(2-chlorobenzyl)-7-fluoro-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one