Valesteramide

Base Information

Chemical Name:Valesteramide
CAS No.:137864-22-3
Molecular Formula:C31H34N2O3
Molecular Weight:482.623
Hs Code.:

Synonyms:N-[2'-cyano-biphenyl-4-yl methyl]-N-valeryl-(L)-valine benzyl ester;

Suppliers and Price of Valesteramide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 20 raw suppliers

Chemical Property of Valesteramide

Chemical Property:

Boiling Point:657.065 °C at 760 mmHg
Flash Point:351.181 °C
Density:1.147 g/cm³

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Valesteramide

There total 7 articles about Valesteramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 638-29-9
n-valeryl chloride

: 137864-23-4
(S)-N-[(2'-Cyano-biphenyl-4-yl)methyl]valine benzyl ester

: 137864-22-3
(S)-2-[(2'-cyanobiphenyl-4-ylmethyl)pentanoylamino]-3-methylbutyric acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20 - 25h; Product distribution / selectivity;

Reference yield:

: N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine benzyl ester hydrochloride

: 638-29-9
n-valeryl chloride

: 137864-22-3
(S)-2-[(2'-cyanobiphenyl-4-ylmethyl)pentanoylamino]-3-methylbutyric acid benzyl ester

Guidance literature:: With sodium carbonate; In dichloromethane;

Reference yield:

: 114772-53-1
2-Cyano-4'-methylbiphenyl

: 137864-22-3
(S)-2-[(2'-cyanobiphenyl-4-ylmethyl)pentanoylamino]-3-methylbutyric acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; hydrogen bromide; 2,2'-azobis(isobutyronitrile) / water; cyclohexane / 3 h / 65 - 68 °C

2.1: sodium hydroxide / water; 5,5-dimethyl-1,3-cyclohexadiene / 20 °C / pH < 8.5 - 9 / Large scale

2.2: 3.42 h / 60 °C / Large scale

2.3: 2 h / 72 °C / Dean-Stark; Large scale

3.1: sodium hydroxide / water; 5,5-dimethyl-1,3-cyclohexadiene / 0.5 h / 50 °C

3.2: 2 h / 40 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen bromide; sodium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; cyclohexane; water; 3.1: |Schotten-Baumann Reaction / 3.2: |Schotten-Baumann Reaction;
DOI:10.1021/op700120n