N-[(2'-Cyano[1,1'-biphenyl]-4-YL)methyl]-N-(1-oxopentyl)-L-valine methyl ester

Base Information

Chemical Name:N-[(2'-Cyano[1,1'-biphenyl]-4-YL)methyl]-N-(1-oxopentyl)-L-valine methyl ester
CAS No.:137863-90-2
Molecular Formula:C25H30N2O3
Molecular Weight:406.525
Hs Code.:
European Community (EC) Number:604-049-4
UNII:6X37Q93CWN
DSSTox Substance ID:DTXSID801137642
Nikkaji Number:J3.276.464I
Mol file:137863-90-2.mol

Synonyms:137863-90-2;Valsartan impurity F;6X37Q93CWN;N-[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]-N-(1-OXOPENTYL)-L-VALINE METHYL ESTER;[N-(2-Cyanobiphenyl-4-yl)methyl]n-valery-(l)-valine methyl ester;UNII-6X37Q93CWN;methyl (2S)-2-[[4-(2-cyanophenyl)phenyl]methyl-pentanoylamino]-3-methylbutanoate;L-Valine, N-((2'-cyano(1,1'-biphenyl)-4-yl)methyl)-N-(1-oxopentyl)-, methyl ester;N-((2'-Cyano(1,1'-biphenyl)-4-yl)methyl)-N-(1-oxopentyl)-L-valine methyl ester;SUQNCOFVJNHEKQ-DEOSSOPVSA-N;SCHEMBL2033;DTXSID801137642;BCP15441;METHYL (2S)-2-[N-({2'-CYANO-[1,1'-BIPHENYL]-4-YL}METHYL)PENTANAMIDO]-3-METHYLBUTANOATE;AKOS015899761;N-[(2'-cyanobiphenyl-4-yl)methyl]-N-valeryl-(L)-valine methylester;N-[(2'-cyanobiphenyl-4-yl)-methyl]-N-valeryl-(L)-valine methyl ester;N-[(2'-cyanobiphenyl-4-yl)methyl]-N-valeryl-(L)-valine methyl ester;N-valeryl-N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester;(S)-2-[(2'-cyano-biphenyl-4-ylmethyl)-pentanoyl-amino]-3-methyl-butyric acid methyl ester;(S)-Methyl 2-(N-((2'-cyano-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate;N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-N-pentanoyl-L-valine Methyl Ester;N-[(2'-CYANOBIPHENYL4-YL)-METHYL]-N-VALERYL-(L)-VALINE METHYL ESTER;N-[(2a(2)-Cyano[1,1a(2)-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine methyl ester;L-Valine, N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-, methyl ester;N-[(2'-Cyano[1,1'-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine methyl ester

Suppliers and Price of N-[(2'-Cyano[1,1'-biphenyl]-4-YL)methyl]-N-(1-oxopentyl)-L-valine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N-[(2''-Cyano[1,1''-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valineMethylEster
250mg
$ 1485.00

Total 59 raw suppliers

Chemical Property of N-[(2'-Cyano[1,1'-biphenyl]-4-YL)methyl]-N-(1-oxopentyl)-L-valine methyl ester

Chemical Property:

Boiling Point:579.3±50.0 °C(Predicted)
PKA:-0.99±0.70(Predicted)
PSA：70.40000
Density:1.12±0.1 g/cm3(Predicted)
LogP:4.94168
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Methanol (slightly)
XLogP3:5.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:10
Exact Mass:406.22564282
Heavy Atom Count:30
Complexity:601

Purity/Quality:

99% ^*data from raw suppliers

N-[(2''-Cyano[1,1''-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valineMethylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C#N)C(C(C)C)C(=O)OC
Isomeric SMILES:CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C#N)[C@@H](C(C)C)C(=O)OC
Uses N-[(2''-Cyano[1,1''-biphenyl]-4-yl)methyl]-N-(1-oxopentyl)-L-valine Methyl Ester is an impurity of the drug Valsartan (V095750), which is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Technology Process of N-[(2'-Cyano[1,1'-biphenyl]-4-YL)methyl]-N-(1-oxopentyl)-L-valine methyl ester

There total 30 articles about N-[(2'-Cyano[1,1'-biphenyl]-4-YL)methyl]-N-(1-oxopentyl)-L-valine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

: 482577-59-3
N-((2'-cyano[1,1'-biphenyl]-4-yl)methyl)-L-valine methyl ester hydrochloride

: 638-29-9
n-valeryl chloride

: 137863-90-2
methyl 2-(N-((2'-cyanobiphenyl-4-yl)methyl)pentanamido)-3-methylbutanoate

Guidance literature:: With potassium carbonate; sodium chloride; In 5,5-dimethyl-1,3-cyclohexadiene; water; at 20 - 28 ℃; Solvent; Reagent/catalyst;