3-Bromo-6-chloro-1-methyl-2(1H)-pyridinone

Base Information

• Chemical Name: 3-Bromo-6-chloro-1-methyl-2(1H)-pyridinone
• CAS No.: 960299-32-5
• Molecular Formula: C₆H₅BrClNO
• Molecular Weight: 222.469
• Mol file: 960299-32-5.mol

Synonyms:

Chemical Property of 3-Bromo-6-chloro-1-methyl-2(1H)-pyridinone

Chemical Property:

• Boiling Point: 269.0±40.0 °C(Predicted)
• PKA: -4.15±0.62(Predicted)
• Density: 1.78±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-6-chloro-1-methylpyridin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Bromo-6-chloro-1-methyl-2(1H)-pyridinone

There total 1 articles about 3-Bromo-6-chloro-1-methyl-2(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

6-chloro-1-1methylpyridin-2(1H)-one (17228-63-6) → 3-bromo-6-chloro-1-methylpyridin-2(1H)-one (960299-32-5) + 5-bromo-6-chloro-1-methylpyridin-2(1H)-one (960299-33-6)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

3-bromo-6-chloro-1-methylpyridin-2(1H)-one (960299-32-5) → C16H10F9NO2

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; 1,2-dimethoxyethane / 3 h / 80 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

Reference yield:

3-bromo-6-chloro-1-methylpyridin-2(1H)-one (960299-32-5) → C17H18F3NOS2

Guidance literature:

Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C / Cooling with ice

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium phosphate / water; 1,2-dimethoxyethane / 3 h / 80 °C

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 9 h / 60 °C

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; caesium carbonate; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

6-chloro-1-1methylpyridin-2(1H)-one