6-Chloro-1-methyl-2(1H)pyridinone

Base Information

• Chemical Name: 6-Chloro-1-methyl-2(1H)pyridinone
• CAS No.: 17228-63-6
• Molecular Formula: C6H6 Cl N O
• Molecular Weight: 143.573
• Hs Code.: 2933399090
• Mol file: 17228-63-6.mol

Synonyms:2(1H)-Pyridone,6-chloro-1-methyl- (8CI); 6-Chloro-1-methyl-1,2-dihydropyridin-2-one;6-Chloro-1-methyl-2(1H)-pyridone; 6-Chloro-1-methyl-2-pyridone;6-Chloro-1-methylpyridin-2(1H)-one

Chemical Property of 6-Chloro-1-methyl-2(1H)pyridinone

Chemical Property:

• Vapor Pressure: 0.00738mmHg at 25°C
• Boiling Point: 269.1°Cat760mmHg
• PKA: -0.98±0.62(Predicted)
• Flash Point: 116.6°C
• PSA: 22.00000
• Density: 1.29g/cm³
• LogP: 1.03870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-1-methylpyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Chloro-1-methylpyridin-2(1H)-one is used in preparation of substituted pyrimidinones for inhibiting the activity of SHP2.

Technology Process of 6-Chloro-1-methyl-2(1H)pyridinone

There total 5 articles about 6-Chloro-1-methyl-2(1H)pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

6-chloro-2-pyridone (16879-02-0) + methyl iodide (74-88-4) → 6-chloro-1-1methylpyridin-2(1H)-one (17228-63-6)

Guidance literature:

With lithium carbonate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00130

Reference yield: 82.0%

6-chloro-2-hydroxypyridine (16879-02-0) + methyl iodide (74-88-4) → 6-chloro-1-1methylpyridin-2(1H)-one (17228-63-6)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In benzene; at 20 ℃; for 24h;

DOI:10.3987/com-99-s18

Reference yield:

2,6-dichloropyridine (2402-78-0) → 6-chloro-1-1methylpyridin-2(1H)-one (17228-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium tert-butylate / tert-butyl alcohol / 24 h / Reflux

2: potassium carbonate / acetone / 4 h / Reflux; Sealed tube

With potassium tert-butylate; potassium carbonate; In acetone; tert-butyl alcohol;

DOI:10.1039/c1ob05082f

upstream raw materials:

6-chloro-2-pyridone

methyl iodide

6-chloro-2-hydroxypyridine

2,6-dichloropyridine

Downstream raw materials:

6-benzyl-1-methylpyridin-2-one

3-bromo-6-chloro-1-methylpyridin-2(1H)-one

5-bromo-6-chloro-1-methylpyridin-2(1H)-one

1-ethyl-3-(4-(7-(1-methyl-6-oxo-1,6-dihydropyridin-2-yl)-4-morpholino-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea