ethyl 3-hydroxy-3-phenylheptanoate

Base Information

• Chemical Name: ethyl 3-hydroxy-3-phenylheptanoate
• CAS No.: 6966-37-6
• Molecular Formula: C15H22 O3
• Molecular Weight: 250.3334
• Mol file: 6966-37-6.mol

Synonyms:Hydrocinnamicacid, b-butyl-b-hydroxy-, ethyl ester (7CI,8CI);NSC 18776

Chemical Property of ethyl 3-hydroxy-3-phenylheptanoate

Chemical Property:

• Vapor Pressure: 3.65E-06mmHg at 25°C
• Boiling Point: 371.1°C at 760 mmHg
• Flash Point: 149.2°C
• Density: 1.044g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 3-hydroxy-3-phenylheptanoate

There total 1 articles about ethyl 3-hydroxy-3-phenylheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.1%

phenyl butyl ketone (1009-14-9) + ethyl bromoacetate (105-36-2) → DL-ethyl-3-hydroxy-3-phenyl heptanoate (6966-37-6)

Guidance literature:

phenyl butyl ketone; ethyl bromoacetate; With zinc; In diethyl ether; benzene; for 5h; Heating;

With sulfuric acid; In diethyl ether; benzene; Further stages.;

Reference yield: 53.8%

DL-ethyl-3-hydroxy-3-phenyl heptanoate (6966-37-6) → DL-3-hydroxy-3-phenyl-heptanamide (863976-08-3)

Guidance literature:

With ammonium hydroxide; In ethanol; at 20 ℃; for 672h;

Reference yield:

DL-ethyl-3-hydroxy-3-phenyl heptanoate (6966-37-6) → C25H30O3

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / benzene / Reflux

2: lithium aluminium tetrahydride / diethyl ether / 0 °C / Inert atmosphere

3: oxygen; 3,7-bis(dimethylamine)phenothiazonium / acetonitrile; dichloromethane / 20 °C / Irradiation

4: hydrogenchloride / water / 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; oxygen; 3,7-bis(dimethylamine)phenothiazonium; toluene-4-sulfonic acid; In diethyl ether; dichloromethane; water; acetonitrile; benzene;

DOI:10.1002/ardp.201600335

upstream raw materials:

phenyl butyl ketone

ethyl bromoacetate

Downstream raw materials:

acide 3-phenyl-heptanoique

DL-3-hydroxy-3-phenyl-heptanamide

β-Butyl-cinnamic-ethylester