Avatrombopag

Base Information

• Chemical Name: Avatrombopag
• CAS No.: 570406-98-3
• Molecular Formula: C29H34Cl2N6O3S2
• Molecular Weight: 649.665
• UNII: 3H8GSZ4SQL
• DSSTox Substance ID: DTXSID30205667
• Nikkaji Number: J3.032.732B
• Wikipedia: Avatrombopag
• Wikidata: Q27257213
• NCI Thesaurus Code: C150559
• RXCUI: 2045726
• Pharos Ligand ID: 85DHWNNHF98L
• Metabolomics Workbench ID: 153062
• ChEMBL ID: CHEMBL2103883
• Mol file: 570406-98-3.mol

Synonyms:1-(3-chloro-5-((4-(4-chloro-2-thienyl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)-2-pyridyl)piperidine-4-carboxylic acid;AKR 501;AKR-501;AKR501;avatrombopag;Doptelet;E5501 compound;YM 477;YM-477;YM477

Chemical Property of Avatrombopag

Chemical Property:

• PKA: 3.04±0.70(Predicted)
• PSA: 161.87000
• Density: 1.440
• LogP: 7.03330
• XLogP3: 4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 7
• Exact Mass: 648.1510867
• Heavy Atom Count: 42
• Complexity: 935

Purity/Quality:

99%, ^*data from raw suppliers

Avatrombopag 98+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)N2CCN(CC2)C3=C(N=C(S3)NC(=O)C4=CC(=C(N=C4)N5CCC(CC5)C(=O)O)Cl)C6=CC(=CS6)Cl
• Recent ClinicalTrials: An Observational, Multicenter Study to Evaluate the Use and Effectiveness of Doptelet? in Patients With ITP
• Recent EU Clinical Trials: A Phase 3b, Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial with an Open-label Extension Phase to Evaluate the Efficacy and Safety of Avatrombopag for the Treatment of Thrombocytopenia in Pediatric Subjects with Immune Thrombocytopenia for ≥6 Months
• Recent NIPH Clinical Trials: Treatment of Thrombocytopenia in Patients With Chronic Liver Disease Undergoing an Elective Procedure
• Description: Avatrombopag is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure.It was the third thrombopoietin receptor agonist approved for the treatment of immune thrombocytopenia and the first approved to treat periprocedural thrombocytopenia in patients with chronic liver disease (thereby providing an alternative to blood transfusions for these patients). Avatrombopag was approved for medical use in the United States in 2018, and in the European Union in 2019.

Technology Process of Avatrombopag

There total 12 articles about Avatrombopag which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate (570403-14-4) → 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid (570406-98-3)

Guidance literature:

With potassium hydroxide; In isopropyl alcohol; at 60 ℃; for 2h; Reagent/catalyst; Solvent;

Reference yield: 94.0%

4-bromo-2-(2-bromoethyl)butanoic acid (128094-80-4) + N-[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]-6-amino-5-chloro-3-pyridinecarboxamide → 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid (570406-98-3)

Guidance literature:

N-[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]-6-amino-5-chloro-3-pyridinecarboxamide; With sodium dodecyl-sulfate; sodium hydrogencarbonate; In water; at 20 ℃; for 0.5h;

4-bromo-2-(2-bromoethyl)butanoic acid; at 80 - 85 ℃;

Reference yield: 92.4%

1-[3-chloro-5-[[[4-(4-chloro-2-thienyl)-5-(4-cyclohexyl-1-piperazinyl)-2-thiazolyl]amino]carbonyl]-2-pyridyl]-4-piperidinylcarboxylic acid methyl ester → 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid (570406-98-3)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 25 - 30 ℃; for 8h;

upstream raw materials:

ethyl 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylate

5-bromo-4-(4-chlorothiophen-2-yl)-2-aminothiazole

4-(4-chlorothiophen-2-yl)-1,3-thiazol-2-amine

4-bromo-2-(2-bromoethyl)butanoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 570406-98-3 AKR-501

Send

Send

Metric Ton KG G Pound L ML

Send

Send