1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL

Base Information

Chemical Name:1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL
CAS No.:289665-56-1
Molecular Formula:C10H14N2O5
Molecular Weight:242.23
Hs Code.:
Mol file:289665-56-1.mol

Synonyms:1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL

Suppliers and Price of 1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL 95.00%
5MG
$ 498.77

Total 2 raw suppliers

Chemical Property of 1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL 95.00% ^*data from reagent suppliers

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Technology Process of 1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL

There total 7 articles about 1,4-ANHYDRO-2,5-DIDEOXY-2-(3,4-DIHYDRO-2,4-DIOXO-1(2H)-PYRIMIDINYL)-D-ARABINO-HEXITOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 66-22-8,144104-68-7,18324-22-6,27072-01-1,2920-92-5,51953-19-6
uracil

: 289665-51-6
6-O-benzoyl-5-deoxy-1,4:2,3-dianhydro-D-allitol

: 289665-57-2
3'-deoxy-3'-(uracil-1-yl)-5'-deoxy-1',4'-anhydro-D-altritol

: 289665-56-1
2'-deoxy-2'-(uracil-1-yl)-5'-deoxy-1',4'-anhydro-D-altritol

Guidance literature:: uracil; 6-O-benzoyl-5-deoxy-1,4:2,3-dianhydro-D-allitol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 85 ℃; for 48h;

With methanol; sodium methylate; at 20 ℃; for 12h;
DOI:10.1016/S0957-4166(00)00136-1

Reference yield:

: 62102-11-8
5-deoxy-1,2-O-isopropylidene-3-O-p-tolylsulfonyl-α-D-xylo-hexofuranose

: 289665-56-1
2'-deoxy-2'-(uracil-1-yl)-5'-deoxy-1',4'-anhydro-D-altritol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / pyridine / 18 h / 20 °C

2.1: TMSOTf / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 53 percent / Et₃SiH / CH₂Cl₂ / 48 h / 0 °C

3.1: 95 percent / t-BuOK / tetrahydrofuran / 0.5 h / -10 °C

4.1: DBU / dimethylformamide / 48 h / 85 °C

4.2: sodium methoxide/MeOH / 12 h / 20 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Esterification / 2.1: Ring cleavage / 2.2: Reduction / 3.1: Cyclization / 4.1: Addition / 4.2: Hydrolysis;
DOI:10.1016/S0957-4166(00)00136-1

Reference yield:

: 43138-33-6
5β-vinyl-4β-tosyl-2α,3α-O-isopropylidene tetrahydrofuran

: 289665-56-1
2'-deoxy-2'-(uracil-1-yl)-5'-deoxy-1',4'-anhydro-D-altritol

Guidance literature:: Multi-step reaction with 5 steps

1.1: BH₃*SMe₂ / tetrahydrofuran / 2 h / 20 °C

1.2: 53.5 percent / NaOH; aq. H₂O₂ / methanol; tetrahydrofuran / 2 h / 20 °C

2.1: 98 percent / pyridine / 18 h / 20 °C

3.1: TMSOTf / CH₂Cl₂ / 0.5 h / 20 °C

3.2: 53 percent / Et₃SiH / CH₂Cl₂ / 48 h / 0 °C

4.1: 95 percent / t-BuOK / tetrahydrofuran / 0.5 h / -10 °C

5.1: DBU / dimethylformamide / 48 h / 85 °C

5.2: sodium methoxide/MeOH / 12 h / 20 °C

With pyridine; trimethylsilyl trifluoromethanesulfonate; dimethylsulfide borane complex; potassium tert-butylate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Reduction / 1.2: Hydrolysis / 2.1: Esterification / 3.1: Ring cleavage / 3.2: Reduction / 4.1: Cyclization / 5.1: Addition / 5.2: Hydrolysis;
DOI:10.1016/S0957-4166(00)00136-1