289665-57-2 Usage
Type of Drug
Potent antiretroviral agent
Purpose
Treatment of HIV/AIDS
Mechanism of Action
Nucleoside analog reverse transcriptase inhibitor
Function
Interferes with the replication of the HIV virus
Structural Similarity
Similar to the natural nucleoside deoxyguanosine
Enzyme Inhibition
Inhibits the activity of the viral reverse transcriptase enzyme
Treatment Approach
Used in combination with other antiretroviral drugs
Therapy Type
Part of highly active antiretroviral therapy (HAART)
Goal
Effectively manage HIV infection and reduce the risk of disease progression
Available Forms
Oral tablets, oral solutions, and injectable formulations
Target Patient Population
Different patient populations based on the form of the drug
Check Digit Verification of cas no
The CAS Registry Mumber 289665-57-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,9,6,6 and 5 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 289665-57:
(8*2)+(7*8)+(6*9)+(5*6)+(4*6)+(3*5)+(2*5)+(1*7)=212
212 % 10 = 2
So 289665-57-2 is a valid CAS Registry Number.
289665-57-2Relevant academic research and scientific papers
Novel isonucleoside analogues: synthesis of 2'-deoxy-2'-nucleobase-5'-deoxy-1',4'-anhydro-D-altritol
Tian,Min,Zhang
, p. 1877 - 1889 (2007/10/03)
A new class of isonucleoside analogues with branched-sugar 2'-deoxy-2'-nucleobase-5'-deoxy-1',4'-anhydro-D-altritol (21, 23a-c) has been synthesized from D-glucose in 11 steps. The construction of branched-chain sugars has been carried out by hydroboration-oxidation of a double bond in the corresponding hexose. The key intermediate 12 was synthesized from the branched-chain sugar 11 by the reductive cleavage reaction in the presence of TMSOTf and triethylsilane. A strong solvent effect was observed in the intramolecular nucleophilic substitution of 12. The protic solvent is favorable to form the bicyclic compound 18 by double S(N)2 substitution. The opening reaction of epoxide 17 by nucleobases was achieved regioselectively to give the desired isonucleosides in reasonable yield. Copyright (C) 2000 Elsevier Science Ltd.
