Ethyl 5-phenyl-2-(3-phenylthioureido)thiophene-3-carboxylate

Base Information

Chemical Name:Ethyl 5-phenyl-2-(3-phenylthioureido)thiophene-3-carboxylate
CAS No.:72625-10-6
Molecular Formula:C₂₀H₁₈N₂O₂S₂
Molecular Weight:382.507
Hs Code.:
DSSTox Substance ID:DTXSID201145582

Synonyms:72625-10-6;Ethyl 5-phenyl-2-(3-phenylthioureido)thiophene-3-carboxylate;starbld0011720;DTXSID201145582;CCG-47704;AKOS003705281;SR-01000637302-1;Ethyl 5-phenyl-2-[[(phenylamino)thioxomethyl]amino]-3-thiophenecarboxylate

Suppliers and Price of Ethyl 5-phenyl-2-(3-phenylthioureido)thiophene-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 5-phenyl-2-(3-phenylthioureido)thiophene-3-carboxylate

Chemical Property:

XLogP3:5.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:382.08097017
Heavy Atom Count:26
Complexity:476

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(SC(=C1)C2=CC=CC=C2)NC(=S)NC3=CC=CC=C3

Technology Process of Ethyl 5-phenyl-2-(3-phenylthioureido)thiophene-3-carboxylate

There total 4 articles about Ethyl 5-phenyl-2-(3-phenylthioureido)thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 62-53-3
aniline

: 85716-86-5
2-isothiocyanato-5-phenyl-3-thiophenecarboxylic acid ethyl ester

: 72625-10-6
5-phenyl-2-(3-phenyl-thioureido)-thiophene-3-carboxylic acid ethyl ester

Guidance literature:: In dichloromethane; for 1h; Ambient temperature;

Reference yield: 44.0%

: 4815-34-3
ethyl 2-amino-5-phenylthiophene-3-carboxylate

: 103-72-0
phenyl isothiocyanate

: 72625-10-6
5-phenyl-2-(3-phenyl-thioureido)-thiophene-3-carboxylic acid ethyl ester

Guidance literature:: In ethanol; Heating;

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 72625-10-6
5-phenyl-2-(3-phenyl-thioureido)-thiophene-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcOH; AcONH₄ / benzene / Heating

1.2: sulfur; Et₂NH / ethanol / 50 °C

2.1: pyridine / 50 °C

With pyridine; ammonium acetate; acetic acid; In benzene;
DOI:10.1016/j.bmcl.2005.02.005