3-acetylphenylboronic acid

Base Information

• Chemical Name: 3-acetylphenylboronic acid
• CAS No.: 1421789-48-1
• Molecular Formula: C₂₂H₂₃N₂O*I
• Molecular Weight: 458.342
• Mol file: 1421789-48-1.mol

Synonyms:

Chemical Property of 3-acetylphenylboronic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-acetylphenylboronic acid

There total 3 articles about 3-acetylphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

pyridine (110-86-1) + C17H19NO (1421789-45-8) → 3-acetylphenylboronic acid (1421789-48-1)

Guidance literature:

With iodine; for 2h; Heating;

DOI:10.1039/c2cc37862k

Reference yield:

1-(3-bromo-5-(tert-butyl)phenyl)ethanone (1124138-68-6) → 3-acetylphenylboronic acid (1421789-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride / toluene / 24 h / Reflux; Inert atmosphere

2: iodine / 2 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; iodine; In toluene; 1: |Stille Cross Coupling;

DOI:10.1039/c2cc37862k

Reference yield:

1,3-dibromo-5-t-butylbenzene (129316-09-2) → 3-acetylphenylboronic acid (1421789-48-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-butyllithium / diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 12 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 24 h / Reflux; Inert atmosphere

3.1: iodine / 2 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; iodine; In diethyl ether; toluene; 2.1: |Stille Cross Coupling;

DOI:10.1039/c2cc37862k

upstream raw materials:

pyridine

C₁₇H₁₉NO

1,3-dibromo-5-t-butylbenzene

1-(3-bromo-5-(tert-butyl)phenyl)ethanone

Downstream raw materials:

C₄₀H₄₂N₂OPt

C₄₁H₄₆N₂O