EPZ011989 (trifluoroacetate)

Base Information

Chemical Name:EPZ011989 (trifluoroacetate)
CAS No.:1598383-41-5
Molecular Formula:C₂HF₃O₂*C₃₅H₅₁N₅O₄
Molecular Weight:719.845
Hs Code.:
Mol file:1598383-41-5.mol

Synonyms:

Suppliers and Price of EPZ011989 (trifluoroacetate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
EPZ-011989trifluoroacetate >98%
100 mg
$ 400.00

DC Chemicals
EPZ-011989trifluoroacetate >98%
50 mg
$ 272.00

DC Chemicals
EPZ-011989trifluoroacetate >98%
10 mg
$ 112.00

ChemScene
EPZ011989trifluoroacetate 98.71%
50mg
$ 280.00

ChemScene
EPZ011989trifluoroacetate 98.71%
10mg
$ 90.00

ChemScene
EPZ011989trifluoroacetate 98.71%
5mg
$ 60.00

Biorbyt Ltd
EPZ-011989 trifluoroacetate
100 mg
$ 615.40

Biorbyt Ltd
EPZ-011989 trifluoroacetate
50 mg
$ 552.50

Biorbyt Ltd
EPZ-011989 trifluoroacetate
10 mg
$ 306.00

Total 5 raw suppliers

Chemical Property of EPZ011989 (trifluoroacetate)

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

EPZ-011989trifluoroacetate >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of EPZ011989 (trifluoroacetate)

There total 8 articles about EPZ011989 (trifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.6%

: 10312-83-1
methoxyacetaldehyde

: 1598383-53-9
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

: 76-05-1
trifluoroacetic acid

: 1598383-41-5
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide trifluoroacetate

Guidance literature:: methoxyacetaldehyde; N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide; With acetic acid; In dichloromethane; at 0 ℃; for 0.333333h;

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 0 ℃; for 2h;

trifluoroacetic acid; In dichloromethane;

Reference yield:

: 1403258-27-4
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-(ethyl)amino)-2-methylbenzoate

: 1598383-41-5
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; copper(l) iodide; diisopropylamine / toluene / 5 h / 80 °C / Inert atmosphere; Sealed tube

3.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 12 h / 20 °C

5.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

8.1: acetic acid / dichloromethane / 0.33 h / 0 °C

8.2: 2 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; carbon tetrabromide; water; sodium hydride; acetic acid; triethylamine; diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2.1: |Sonogashira Cross-Coupling;

Reference yield:

: 1598383-49-3
methyl 3-(((trans)-4-((tert-butoxycarbonyl)-(methyl)amino)cyclohexyl)(ethyl)amino)-5-(3-hydroxyprop-1-yn-1-yl)-2-methylbenzoate

: 1598383-41-5
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-((2-methoxyethyl)(methyl)amino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 12 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

4.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

6.1: acetic acid / dichloromethane / 0.33 h / 0 °C

6.2: 2 h / 0 °C

With carbon tetrabromide; water; acetic acid; triethylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;