N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Base Information

Chemical Name:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide
CAS No.:1598383-53-9
Molecular Formula:C₃₂H₄₅N₅O₃
Molecular Weight:547.741
Hs Code.:

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Synonyms:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

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Chemical Property of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

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Technology Process of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

There total 7 articles about N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1598383-52-8
tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

: 1598383-53-9
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 1598383-48-2
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)(methyl)amino)cyclohexyl)(ethyl)amino)-2-methylbenzoate

: 1598383-53-9
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; copper(l) iodide; diisopropylamine / toluene / 5 h / 80 °C / Inert atmosphere; Sealed tube

2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 12 h / 20 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

5.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

5.2: 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; carbon tetrabromide; water; triethylamine; diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1.1: |Sonogashira Cross-Coupling;

Reference yield:

: 1403258-27-4
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-(ethyl)amino)-2-methylbenzoate

: 1598383-53-9
N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl((trans)-4-(methylamino)cyclohexyl)amino)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; copper(l) iodide; diisopropylamine / toluene / 5 h / 80 °C / Inert atmosphere; Sealed tube

3.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 12 h / 20 °C

5.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

6.2: 20 °C

7.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; carbon tetrabromide; water; sodium hydride; triethylamine; diisopropylamine; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2.1: |Sonogashira Cross-Coupling;