Ethyl 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: Ethyl 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylate
• CAS No.: 946061-21-8
• Molecular Formula: C8H9ClN2O3
• Molecular Weight: 216.62
• Hs Code.: 2933199090
• Mol file: 946061-21-8.mol

Synonyms:ETHYL 5-CHLORO-4-FORMYL-1-METHYL-1H-PYRAZOLE-3-CARBOXYLATE;1H-pyrazole-3-carboxylic acid, 5-chloro-4-forMyl-1-Methyl-, ethyl ester

Chemical Property of Ethyl 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylate

Chemical Property:

• Vapor Pressure: 3E-05mmHg at 25°C
• Boiling Point: 356.1°C at 760 mmHg
• Flash Point: 169.1°C
• PSA: 61.19000
• Density: 1.37
• LogP: 1.06270
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylate

There total 2 articles about Ethyl 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (51986-17-5) → 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (946061-21-8)

Guidance literature:

With trichlorophosphate; at 90 ℃; for 3h;

DOI:10.1021/acs.jafc.2c00092

Reference yield:

ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate (51986-17-5) → 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (946061-21-8)

Guidance literature:

ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate; With trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 0 - 110 ℃; for 4.5h;

With water; sodium hydrogencarbonate; for 2h;

Reference yield:

p-cresol (106-44-5) + 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester (946061-21-8) → 4-formyl-1-methyl-5-p-toluyloxy-1H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:

p-cresol; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester; In N,N-dimethyl-formamide; at 110 ℃; for 1.5h;

upstream raw materials:

ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

N,N-dimethyl-formamide