51986-17-5

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate is used as a chemical intermediate for the synthesis of various drugs and medicines. Its unique structural features, including the hydroxy and carboxylate groups, make it a valuable component in the development of new pharmaceutical compounds.
Used in Medicinal Chemistry Research:
Ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate is employed in medicinal chemistry research to explore its potential pharmacological effects and applications in the treatment of various diseases and conditions. The presence of functional groups in its structure allows for further modification and optimization to enhance its biological activity and therapeutic potential.
Used in Drug Development:
Ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate is utilized in drug development to create novel therapeutic agents with improved efficacy, safety, and selectivity. Its versatile chemical structure enables the design of targeted drug candidates for specific diseases and conditions, contributing to the advancement of modern medicine.

InChI:InChI=1/C7H10N2O3/c1-3-12-7(11)5-4-6(10)9(2)8-5/h4,10H,3H2,1-2H3

Upstream product

• 60-34-4 methylhydrazine 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 302-15-8 methylhydrazine sulfuric acid 
• 40876-98-0 sodium 1,4-diethoxy-1,4-dioxobut-2-en-2-olate 
• 88330-76-1 diethyl oxalacetate sodium salt 
• 64-17-5 ethanol 
• 3702-98-5 ethyl 4,4,4-trichloroacetoacetate 
• 7339-53-9 methyl hydrazine hydrochloride 
• 687-00-3 methyl 4,4,4-trichloroacetoacetate 

Downstream Products

• 85230-34-8 5-Hydroxy-1-methyl-4-o-tolylcarbamoyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 58364-97-9 5-hydroxy-1-methyl-1h-pyrazole-3-carboxylic acid 
• 1269293-48-2 ethyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate 
• 946061-21-8 5-chloro-4-formyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 81292-21-9 3-(3-ethoxycarbonyl-5-hydroxy-1-methylpyrazol-4-yl)-N-propylpropanamide 
• 85230-32-6 4-(2,5-Dichloro-phenylcarbamoyl)-5-hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 85230-35-9 5-Hydroxy-1-methyl-4-(3-trifluoromethyl-phenylcarbamoyl)-1H-pyrazole-3-carboxylic acid ethyl ester 
• 85230-30-4 4-(3-Chloro-phenylcarbamoyl)-5-hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 81292-17-3 3-ethoxycarbonyl-1-methylpyrano<2,3-c>pyrazol-6(1H)-one 
• 85230-28-0 3-ethoxycarbonyl-1-methyl-4-(N-phenylcarbamoyl)pyrazolin-5-one 
• 85230-29-1 4-(2-Chloro-phenylcarbamoyl)-5-hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 
• 85230-31-5 4-(4-Chloro-phenylcarbamoyl)-5-hydroxy-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis method of 5-bromine-1-methyl-1H-pyrazole-3-amine

The invention discloses a synthesis method of 5-bromine-1-methyl-1H-pyrazole-3-amine. The method comprises the steps of condensing diethyl butynedioate serving as a raw material with methylhydrazine to obtain 5-hydroxyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester, and reacting the 5-hydroxyl-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester with phosphorus oxybromide to obtain 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid ethyl ester; hydrolyzing in a sodium hydroxide alcohol solution to obtain 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid, reacting the 5-bromine-1-methyl-1H-pyrazole-3-carboxylic acid with dimethyl azide phosphate and tert-butyl alcohol to obtain tert-butyl (5-bromine-1-methyl-1H-pyrazole-3-yl) carbamate, and hydrolyzing in trifluoroacetic acid to obtain the5-bromine-1-methyl-1H-pyrazole-3-amine. The method has the advantages of simple synthesis route, reasonable process selection, low raw material cost, simple and easily available raw materials, convenient operation and post-treatment, and no use of highly toxic reagents, and overcomes the defects of expensive and unavailable raw materials, unsafe operation, difficult amplification and the like in the existing synthesis process.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders and primary brain cancer. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders and primary brain cancer.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

PROCESS FOR PRODUCTION OF 5-ALKOXY-4-HYDROXYMETHYLPYRAZOLE COMPOUND

The present invention relates to a process for producing a 5-alkoxy-4-hydroxymethylpyrazole compound in a simple manner and with good efficiency. A process for producing a 5-alkoxy-4-hydroxymethylpyrazole compound represented by the general formula (3) which comprises reacting a pyrazole compound represented by the general formula (1) (wherein R1 is a substituent such as alkyl group, substituted or unsubstituted group or the like, and R2 is an electron withdrawing group) with a compound represented by the general formula (2) ????????L-R3?????(2) (wherein L is a leaving group and R3 is a substituent such as substituted or unsubstituted alkyl group or the like) in the presence of a base and formaldehyde.

TRISAZO-DYES WITH A PYRAZOLYL END GROUP AND THEIR USE IN INK-JET PRINTING

A compound of Formula (1) or a salt thereof: A-N=N-D-N=N-B-N=N-A' wherein A is an optionally substituted aryl, heteroaryl, non-aromatic heterocyclic or alkenyl group; D is an optionally substituted, optionally metallised 1,8-dihydroxynaphthalene group; B is an optionally substituted organic linking group; and A' is an optionally substituted pyrazolyl group which does not have an aromatic group as a substituent directly attached to either of the nitrogen atoms of the pyrazolyl ring. Also provided are compositions, inks, ink sets, substrates and cartridges all containing the compound or salt and printing processes using the compound or salt. The compounds and salts are especially useful for ink-jet printing.

BINDING INHIBITOR OF SPHINGOSINE-1-PHOSPHATE

The present invention aims to provide compounds which have an inhibitory effect on the binding between S1P and its receptor Edg-1(S1P1) and which are useful for pharmaceutical purposes. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: [wherein Ar represents a monocyclic heterocyclic ring containing one or two nitrogen atoms, A represents an oxygen atom or the like, Y1, Y2 and Y3 each represent a carbon atom or a nitrogen atom, R1 represents a hydrogen atom, a C1-C6 alkyl group or the like, R2 represents a C1-C6 alkyl group, a C3-C8 cycloalkyl group or the like, R3 represents a C1-C18 alkyl group or the like, R4 represents a hydrogen atom or a C1-C6 alkyl group, and R5 represents a C1-C10 alkyl group or the like].

PROCESS FOR PRODUCING 5-HYDROXY-4-THIOMETHYLPYRAZOLE COMPOUND

A pyrazole compound represented by general formula (1) is reacted with a sulfur compound represented by general formula (2) in the presence of a base and formaldehyde, to thereby produce a 5-hydroxy-4-thiomethylpyrazole compound represented by general formula (3). The 5-hydroxy-4-thiomethylpyrazole compound may easily be produced in a good yield, by using such a process. Further, this process may easily provide the 5-hydroxy-4-thiomethylpyrazole compound under a mild condition in a single step, without using a special apparatus, an expensive catalyst, or a transition metal, etc. In addition, this process may be conducted substantially without producing a harmful waste which can be derived from a catalyst, etc., and therefore this process is friendly to the environment and industrially valuable.

1,1,1-Trichloro-4,4-diethoxy-3-buten-2-one and its Trichloroacetylacetate Derivatives: Synthesis and Applications in Regiospecific Preparation of Azoles

The synthesis of 1,1,1-trichloro-4,4-diethoxy-3-buten-2-one and three trichloroacetylacetate derivatives from the acylation reaction of respective trialkyl orthoacetates and orthopropionates with trichloroacetyl chloride in good yields, is reported. The t

Process for producing pyrazolecarboxamide derivative

A process for producing a pyrazolecarboxamide derivative represented by formula (C) which comprises reacting a pyrazolecarboxylic ester compound represented by formula (A) with an amine compound represented by formula (B) in the presence of a Lewis acid: STR1 wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group; R2 represents a substituted or unsubstituted alkyl group; and R3 and R4 each represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, provided that R3 and R4 may be bonded to each other to form a ring.