trans-N-Carbobenzoxy-β-amino>ethyl>phenoxy>proline

Base Information

• Chemical Name: trans-N-Carbobenzoxy-β-amino>ethyl>phenoxy>proline
• CAS No.: 89088-17-5
• Molecular Formula: C₃₅H₄₁N₃O₈
• Molecular Weight: 631.726

Synonyms:

Chemical Property of trans-N-Carbobenzoxy-β-amino>ethyl>phenoxy>proline

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-N-Carbobenzoxy-β-amino>ethyl>phenoxy>proline

There total 11 articles about trans-N-Carbobenzoxy-β-amino>ethyl>phenoxy>proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

<(benzyloxycarbonyl)oxy>-5-norbornene-2,3-dicarboximide + trans-β-amino>ethyl>phenoxy>proline (89105-91-9,89162-89-0,89162-90-3,89162-91-4) → trans-N-Carbobenzoxy-β-amino>ethyl>phenoxy>proline (89088-17-5,89088-18-6,89088-19-7,89088-20-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; water; at 25 ℃; Title compound not separated from byproducts;

DOI:10.1021/jo00180a011

Reference yield: 94.0%

(tert-butoxycarbonyl)-L-phenylalanine N-hydroxysuccinimide ester (3674-06-4,3674-18-8,74124-84-8) + trans-N-Carbobenzoxy-β-ethyl>phenoxy>proline (89088-25-5) → trans-N-Carbobenzoxy-β-amino>ethyl>phenoxy>proline (89088-17-5,89088-18-6,89088-19-7,89088-20-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1. 2min. 25 deg C, 2. 30 min, 25 deg C, ethyl acetate;

DOI:10.1021/jo00180a011

Reference yield:

tyrosamine (51-67-2) → trans-N-Carbobenzoxy-β-amino>ethyl>phenoxy>proline (89088-17-5,89088-18-6,89088-19-7,89088-20-0)

Guidance literature:

Multi-step reaction with 6 steps

1: 92 percent / ethyl acetate / 0.5 h / 25 °C

2: 1. Thallium Ethoxide / 1. ether, 2. DMF, 1.5h, room temperature

3: 0.420 g / NaOH / tetrahydrofuran; H₂O / 1.5 h / 25 °C

4: 0.143 g / dimethylamine borane / acetic acid / 0.5 h / 25 °C

5: 94 percent / triethylamine / tetrahydrofuran; H₂O / 25 °C

6: 94 percent / 1. TFA, 2. DIPEA / 1. 2min. 25 deg C, 2. 30 min, 25 deg C, ethyl acetate

With sodium hydroxide; thallium (I) ethoxide; dimethylamine borane; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; water; acetic acid; ethyl acetate;

DOI:10.1021/jo00180a011

upstream raw materials:

trans-β-amino>ethyl>phenoxy>proline

(tert-butoxycarbonyl)-L-phenylalanine N-hydroxysuccinimide ester

trans-N-Carbobenzoxy-β-ethyl>phenoxy>proline

tyrosamine

Downstream raw materials:

(5S,8RS,9RS)-N^α,9-Ethylene-5-benzyl-N⁸-carbobenzoxy-1,2-dihydro-p-phencyclopeptine

3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid

Dihydromauritine A

(5S,8R,9R)-5-Benzyl-1,2-dihydro-N^α-(N,N-dimethyl-L-alanyl-L-valyl)-N^α,9-ethylene-p-phencyclopeptine

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