3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid

Base Information

• Chemical Name: 3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid
• CAS No.: 89088-32-4
• Molecular Formula: C₂HF₃O₂*C₃₆H₃₆N₄O₈
• Molecular Weight: 766.728

Synonyms:

Chemical Property of 3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid

There total 14 articles about 3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tyrosamine (51-67-2) → 3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid (89088-32-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 92 percent / ethyl acetate / 0.5 h / 25 °C

2: 1. Thallium Ethoxide / 1. ether, 2. DMF, 1.5h, room temperature

3: 0.420 g / NaOH / tetrahydrofuran; H₂O / 1.5 h / 25 °C

4: 0.143 g / dimethylamine borane / acetic acid / 0.5 h / 25 °C

5: 94 percent / triethylamine / tetrahydrofuran; H₂O / 25 °C

6: 94 percent / 1. TFA, 2. DIPEA / 1. 2min. 25 deg C, 2. 30 min, 25 deg C, ethyl acetate

7: 100 percent / pyridine / 4 h / 25 °C

8: 0.05 h / 25 °C

With sodium hydroxide; thallium (I) ethoxide; dimethylamine borane; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; pyridine; water; acetic acid; ethyl acetate;

DOI:10.1021/jo00180a011

Reference yield:

(tert-butoxycarbonyl)-L-phenylalanine N-hydroxysuccinimide ester (3674-06-4,3674-18-8,74124-84-8) → 3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid (89088-32-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 98 percent / DIPEA / ethyl acetate / 20 h / 25 °C

2: 1. thallium ethoxide / 1. ether, 25 deg C, 2. a. DMF, 1h, 25 deg C, b. 20h, -15 deg C

3: 1.44 g / NaOH / tetrahydrofuran / 1 h / 25 °C

4: dimethylamine borane / acetic acid / 0.25 h / 25 °C

5: 100 percent / triethylamine / tetrahydrofuran; H₂O / 25 °C

6: 100 percent / pyridine / 4 h / 25 °C

7: 0.05 h / 25 °C

With sodium hydroxide; thallium (I) ethoxide; dimethylamine borane; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; water; acetic acid; ethyl acetate;

DOI:10.1021/jo00180a011

Reference yield:

N-t-butoxycarbonyl-tyramine (64318-28-1) → 3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid (89088-32-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 1. Thallium Ethoxide / 1. ether, 2. DMF, 1.5h, room temperature

2: 0.420 g / NaOH / tetrahydrofuran; H₂O / 1.5 h / 25 °C

3: 0.143 g / dimethylamine borane / acetic acid / 0.5 h / 25 °C

4: 94 percent / triethylamine / tetrahydrofuran; H₂O / 25 °C

5: 94 percent / 1. TFA, 2. DIPEA / 1. 2min. 25 deg C, 2. 30 min, 25 deg C, ethyl acetate

6: 100 percent / pyridine / 4 h / 25 °C

7: 0.05 h / 25 °C

With sodium hydroxide; thallium (I) ethoxide; dimethylamine borane; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; pyridine; water; acetic acid;

DOI:10.1021/jo00180a011

upstream raw materials:

p-Nitrophenyl N-Carbobenzoxy-trans-β-amino>ethyl>phenoxy>prolinate

trifluoroacetic acid

tyrosamine

N-t-butoxycarbonyl-tyramine

Downstream raw materials:

(5S,8RS,9RS)-N^α,9-Ethylene-5-benzyl-N⁸-carbobenzoxy-1,2-dihydro-p-phencyclopeptine

Dihydromauritine A

(5S,8R,9R)-5-Benzyl-1,2-dihydro-N^α-(N,N-dimethyl-L-alanyl-L-valyl)-N^α,9-ethylene-p-phencyclopeptine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 89088-32-4 3-{4-[2-(2-Amino-3-phenyl-propionylamino)-ethyl]-phenoxy}-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-(4-nitro-phenyl) ester; compound with trifluoro-acetic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send