Technology Process of cis-5-(2-hydroxyethyl)-1-(p-tolylsulphonyl)proline ethyl ester
There total 8 articles about cis-5-(2-hydroxyethyl)-1-(p-tolylsulphonyl)proline ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 59 percent / aq. HCl / diethyl ether / 0.67 h / Ambient temperature
2: CH2Cl2
3: 88 percent / AgBF4 / CH2Cl2 / 72 h / Ambient temperature
4: CF3CO2H / CH2Cl2 / Ambient temperature
5: pyridine / 0 °C
6: 1) B2H6, 2) aq. NaOH, 30percent aq. H2O2 / 1) THF, 20 deg C, 20 min, 2) 30 min, room temp.
With
pyridine; hydrogenchloride; sodium hydroxide; dihydrogen peroxide; trifluoroacetic acid; diborane;
silver tetrafluoroborate;
In
diethyl ether; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 83 percent / AgBF4 / CH2Cl2 / 65 h / Ambient temperature
2: NaI, (CH3)3SiCl / acetonitrile / 2 h / Heating
3: pyridine / 0 °C
4: 1) B2H6, 2) aq. NaOH, 30percent aq. H2O2 / 1) THF, 20 deg C, 20 min, 2) 30 min, room temp.
With
pyridine; sodium hydroxide; chloro-trimethyl-silane; dihydrogen peroxide; sodium iodide; diborane;
silver tetrafluoroborate;
In
dichloromethane; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / AgBF4 / CH2Cl2 / 72 h / Ambient temperature
2: CF3CO2H / CH2Cl2 / Ambient temperature
3: pyridine / 0 °C
4: 1) B2H6, 2) aq. NaOH, 30percent aq. H2O2 / 1) THF, 20 deg C, 20 min, 2) 30 min, room temp.
With
pyridine; sodium hydroxide; dihydrogen peroxide; trifluoroacetic acid; diborane;
silver tetrafluoroborate;
In
dichloromethane;
