C₂₈H₃₈N₄O₄*ClH

Base Information

• Chemical Name: C₂₈H₃₈N₄O₄*ClH
• CAS No.: 1091682-39-1
• Molecular Formula: C₂₈H₃₈N₄O₄*ClH
• Molecular Weight: 531.095
• Mol file: 1091682-39-1.mol

Synonyms:

Chemical Property of C₂₈H₃₈N₄O₄*ClH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₃₈N₄O₄*ClH

There total 5 articles about C₂₈H₃₈N₄O₄*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C33H46N4O6 → C28H38N4O4*ClH (1091682-39-1)

Guidance literature:

With hydrogenchloride; In water; ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

para-acetamidobenzaldehyde (122-85-0) → C28H38N4O4*ClH (1091682-39-1)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C

2: sodium hydroxide / water; tetrahydrofuran / 20 °C

3: hydrogenchloride / water; ethyl acetate / 20 °C

4: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

5: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; dmap; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2016.04.086

Reference yield:

C22H27N3O3*ClH → C28H38N4O4*ClH (1091682-39-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

2: hydrogenchloride / water; ethyl acetate / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; ethyl acetate;

DOI:10.1016/j.bmcl.2016.04.086

upstream raw materials:

1-(tert-butoxycarbonyl)-4-aminopiperidine

para-acetamidobenzaldehyde

Downstream raw materials:

(R)-N-{(S)-1-[4-(4-acetylamino-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-propionamide