ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE

Base Information

• Chemical Name: ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE
• CAS No.: 40019-21-4
• Molecular Formula: C6H8N2O3
• Molecular Weight: 156.141
• Hs Code.: 2934999090
• Mol file: 40019-21-4.mol

Synonyms:ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE;3-Methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester

Chemical Property of ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE

Chemical Property:

• Boiling Point: 238.0±23.0 °C(Predicted)
• PKA: -2.95±0.30(Predicted)
• PSA: 65.22000
• Density: 1 +-.0.06 g/cm3(Predicted)
• LogP: 0.55470
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Ethyl3-Methyl-1,2,4-oxadiazole-5-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE

There total 4 articles about ETHYL 3-METHYL-1,2,4-OXADIAZOLE-5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Ethyl oxalyl chloride (4755-77-5) + acetamide oxime (118493-85-9,117771-39-8,1141922-26-0,1429624-21-4) → 3-methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester (40019-21-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 80 ℃; for 2.5h;

DOI:10.1021/jm0407613

Reference yield: 63.0%

Ethyl oxalyl chloride (4755-77-5) + 1-(hydroxyimino)ethylamine (22059-22-9,117771-39-8,118453-50-2,118464-69-0,118493-85-9,1141922-26-0,1429624-21-4) → 3-methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester (40019-21-4)

Guidance literature:

With pyridine; In dichloromethane; for 14h; Reflux;

Reference yield:

Ethyl oxalyl chloride (4755-77-5) + N-hydroxyacetamidine (118493-85-9,117771-39-8,1141922-26-0,1429624-21-4) → 3-methyl-[1,2,4]oxadiazole-5-carboxylic acid ethyl ester (40019-21-4)

Guidance literature:

With pyridine;

upstream raw materials:

Ethyl oxalyl chloride

acetamide oxime

N-hydroxyacetamidine

1-(hydroxyimino)ethylamine

Downstream raw materials:

3-methyl-1,2,4-oxadiazole-5-carbaldehyde

N-(2-chlorophenyl)-3-methyl-1,2,4-oxadiazole-5-carboxamide

3-methyl-1,2,4-oxadiazole-5-carbohydrazide

(3-methyl-1,2,4-oxadiazol-5-yl)methanol

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