(R)-2-cyano-2-methyl-6-phenylhexamide

Base Information

• Chemical Name: (R)-2-cyano-2-methyl-6-phenylhexamide
• CAS No.: 157096-33-8
• Molecular Formula: C₁₄H₁₈N₂O
• Molecular Weight: 230.31
• Mol file: 157096-33-8.mol

Synonyms:

Chemical Property of (R)-2-cyano-2-methyl-6-phenylhexamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-cyano-2-methyl-6-phenylhexamide

There total 6 articles about (R)-2-cyano-2-methyl-6-phenylhexamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-Cyano-2-methyl-6-phenyl-hexanoyl chloride → (R)-2-cyano-2-methyl-6-phenylhexamide (157096-33-8)

Guidance literature:

With ammonium hydroxide; In water; at -10 ℃; for 1h;

DOI:10.1016/S0040-4020(01)89377-7

Reference yield:

benzyltriphenylphosphonium chloride (1100-88-5) → (R)-2-cyano-2-methyl-6-phenylhexamide (157096-33-8)

Guidance literature:

Multi-step reaction with 5 steps

1: n-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C

2: hydrogen / 5percent Pd/C / ethanol / 1 h / Ambient temperature

3: 10percent KOH / ethanol; H₂O / 1 h / 50 °C

4: PCl₅ / hexane / 1 h / Ambient temperature

5: 25percent NH₃ / H₂O / 1 h / -10 °C

With potassium hydroxide; ammonium hydroxide; n-butyllithium; phosphorus pentachloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; water;

DOI:10.1016/S0040-4020(01)89377-7

Reference yield:

(R)-isopropyl 2-cyano-2-methyl-5-oxopentanoate (143619-32-3) → (R)-2-cyano-2-methyl-6-phenylhexamide (157096-33-8)

Guidance literature:

Multi-step reaction with 5 steps

1: n-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C

2: hydrogen / 5percent Pd/C / ethanol / 1 h / Ambient temperature

3: 10percent KOH / ethanol; H₂O / 1 h / 50 °C

4: PCl₅ / hexane / 1 h / Ambient temperature

5: 25percent NH₃ / H₂O / 1 h / -10 °C

With potassium hydroxide; ammonium hydroxide; n-butyllithium; phosphorus pentachloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; water;

DOI:10.1016/S0040-4020(01)89377-7

upstream raw materials:

benzyltriphenylphosphonium chloride

(R)-isopropyl 2-cyano-2-methyl-5-oxopentanoate

isopropyl (R)-2-cyano-2-methyl-6-phenylhexanoate