N-BOC-DL-PIPECOLINIC ACID

Base Information

• Chemical Name: N-BOC-DL-PIPECOLINIC ACID
• CAS No.: 118552-55-9
• Molecular Formula: C₁₁H₁₉NO₄
• Molecular Weight: 229.276
• Mol file: 118552-55-9.mol

Synonyms:BOC-DL-HOMOPROLINE;BOC-DL-HOPRO-OH;1-N-BOC-2-PIPERIDINECARBOXYLIC ACID;L-N-tert-butoxycarbonyl-pipecolic acid;BOC-DL-PIPECOLIC ACID;BOC-DL-PIC(2)-OH;RARECHEM AH CK 0059;BOC-L-pipecolic acid;N-BOC-PIPERIDINE-2-CARBOXYLIC ACID;BOC-DL-PIP-OH;BOC-DL-HOMOPRO-OH;orN-Boc-2-Piperidinecarboxylicacid;

Chemical Property of N-BOC-DL-PIPECOLINIC ACID

Chemical Property:

• Vapor Pressure: 6.15E-06mmHg at 25°C
• Melting Point: 130-133oC
• Boiling Point: 353.2oC at 760 mmHg
• Flash Point: 167.41oC
• PSA: 66.84000
• Density: 1.164g/cm3
• LogP: 1.79850

Purity/Quality:

99% ^*data from raw suppliers

(R)-N-BOC-2-PIPERIDINECARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-DL-PIPECOLINIC ACID

There total 1 articles about N-BOC-DL-PIPECOLINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-N-tert-butoxycarbonyl-4,5-dehydropipecolic acid → L-N-tert-butoxycarbonyl-4,5-dideutero-pipecolic acid + L-N-tert-butoxycarbonyl-pipecolic acid (26250-84-0,28697-17-8,98303-20-9,118552-55-9)

Guidance literature:

With palladium 10% on activated carbon; deuterium; In methanol;

DOI:10.1016/j.chembiol.2010.01.016

Reference yield: 100.0%

C69H138O8S2Si4 (126789-43-3) + L-N-tert-butoxycarbonyl-pipecolic acid (26250-84-0,28697-17-8,98303-20-9,118552-55-9) → C80H155NO11S2Si4 (126789-44-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at -78 - -10 ℃; for 21h;

DOI:10.1021/ja00164a023

Reference yield: 91.0%

L-N-tert-butoxycarbonyl-pipecolic acid (26250-84-0,28697-17-8,98303-20-9,118552-55-9) + triglycine benzyl ester toluenesulfonic acid salt → 2-[({[(benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester (552318-55-5)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 5 - 20 ℃; for 72h;

DOI:10.1039/b206570n

Downstream raw materials:

C₈₀H₁₅₅NO₁₁S₂Si₄

2-[({[(benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-methyl)-carbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

Refernces