126789-44-4

Basic information

• Product Name: C₈₀H₁₅₅NO₁₁S₂Si₄
• Synonyms: C₈₀H₁₅₅NO₁₁S₂Si₄
• CAS NO: 126789-44-4
• Molecular Weight: 1483.58
• Mol File: 126789-44-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₈₀H₁₅₅NO₁₁S₂Si₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₈₀H₁₅₅NO₁₁S₂Si₄(126789-44-4)
• EPA Substance Registry System: C₈₀H₁₅₅NO₁₁S₂Si₄(126789-44-4)

Safety Data

• Hazardous Substances Data: 126789-44-4(Hazardous Substances Data)

Upstream product

• 126788-95-2 [(2R,5R,6S,8R)-9-Benzyloxy-4,6-dimethoxy-5-(4-methoxy-benzyloxy)-2,8-dimethyl-nonyloxy]-tert-butyl-dimethyl-silane 
• 126789-01-3 2,2-Dimethyl-propionic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-8-[1,3]dithian-2-yl-4,6-dimethoxy-2-methyl-nonyl ester 
• 126788-99-6 2,2-Dimethyl-propionic acid (2R,4S,5R,6S,8R)-5-(tert-butyl-dimethyl-silanyloxy)-4,6-dimethoxy-2,8-dimethyl-9-oxo-nonyl ester 
• 126789-00-2 2,2-Dimethyl-propionic acid (2R,4S,5R,6S,8R)-8-[1,3]dithian-2-yl-5-hydroxy-4,6-dimethoxy-2-methyl-nonyl ester 
• 126788-96-3 (2R,4S,5R,8R)-9-(tert-Butyl-dimethyl-silanyloxy)-4,6-dimethoxy-2,8-dimethyl-nonane-1,5-diol 
• 127492-56-2 C₆₈H₁₂₄O₉S₂Si₃ 
• 127492-57-3 (1E,9E)-(3S,4R,5S,7R,8R,12S,14S,15R,16S,18R)-8-Allyl-7,15-bis-(tert-butyl-dimethyl-silanyloxy)-18-[1,3]dithian-2-yl-14,16-dimethoxy-1-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,4,10,12-tetramethyl-nonadeca-1,9-diene-3,5-diol 
• 127492-55-1 C₇₆H₁₂₉F₃O₁₃S₃Si₃ 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 118977-91-6 C₇₅H₁₅₂O₈S₂Si₅ 
• 116386-70-0 (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enoic acid methoxy-methyl-amide 
• 118949-48-7 (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-(tert-butyl-dimethyl-silanyloxy)-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enal 
• 118977-90-5 (E)-(2S,3R,5S,6R,7S)-2-Allyl-3-hydroxy-9-((1R,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-6,8-dimethyl-7-triethylsilanyloxy-5-triisopropylsilanyloxy-non-8-enoic acid methoxy-methyl-amide 
• 118227-60-4 tert-Butyl-[(1R,2S,4R)-6-(diphenyl-phosphinoyl)-1-((1S,3R)-3-[1,3]dithian-2-yl-1-methoxy-butyl)-2-methoxy-4-methyl-heptyloxy]-dimethyl-silane 

Downstream Products

• 118977-92-7 C₇₇H₁₄₉NO₁₂Si₄ 
• 126789-45-5 C₇₉H₁₅₅NO₁₃Si₄ 

Relevant articles and documents

A Formal Synthesis of FK-506. Exploration of Some Alternatives to Macrolactamization

The coupling of the previously described subunits 2, 3, and 4 is described.The C28-C27 E-double bond is fashioned from a sulfurane induced dehydration of alcohol 11.The C19-C20 E-double bond was constructed via a modified Julia process culminating in a reductive elimination of a vicinal trifluoroacetoxy sulfone (see 22 -> 23 -> 24 and 25).The synthesis of intermediates anticipating potential macrolactonization are also described.

Total Synthesis of the Immunosuppressant (-)-FK-506

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