Ethyl pyrrolidine-3-carboxylate hydrochloride

Base Information

• Chemical Name: Ethyl pyrrolidine-3-carboxylate hydrochloride
• CAS No.: 80028-44-0
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.647
• Hs Code.: 2933990090
• Mol file: 80028-44-0.mol

Synonyms:3-Pyrrolidinecarboxylic acid, ethyl ester, hydrochloride (1:1);

Chemical Property of Ethyl pyrrolidine-3-carboxylate hydrochloride

Chemical Property:

• Vapor Pressure: 0.0462mmHg at 25°C
• Melting Point: 17-42°C
• Boiling Point: 233.1 °C at 760 mmHg
• Flash Point: 94.7 °C
• PSA: 38.33000
• LogP: 1.28980
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl pyrrolidine-3-carboxylate hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl pyrrolidine-3-carboxylate, HCl

Technology Process of Ethyl pyrrolidine-3-carboxylate hydrochloride

There total 4 articles about Ethyl pyrrolidine-3-carboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-t-butyloxycarbonylpyrrole-3-carboxylic acid ethyl ester (170844-49-2,1421256-03-2) → ethyl pyrrolidine-3-carboxylate hydrochloride (80028-44-0,1807350-90-8)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 3h;

Reference yield:

1-benzyl-3-(ethoxycarbonyl)-5-pyrrolidinone (5733-87-9) → ethyl pyrrolidine-3-carboxylate hydrochloride (80028-44-0,1807350-90-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / borane / tetrahydrofuran / 0.25 h

2: 1.) hydrogen, 2.) HCl / 1.) 5percent palladim on carbon / 1.) ethanol, 40 psi, 48 h, 2.) ethanol

With hydrogenchloride; borane; hydrogen; palladium on activated charcoal; In tetrahydrofuran;

DOI:10.1021/ja00367a025

Reference yield:

1-benzyl-3-carboethoxypyrrolidine (5747-92-2) → ethyl pyrrolidine-3-carboxylate hydrochloride (80028-44-0,1807350-90-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; Yield given. Multistep reaction; 1.) ethanol, 40 psi, 48 h, 2.) ethanol;

DOI:10.1021/ja00367a025

upstream raw materials:

1-benzyl-3-carboethoxypyrrolidine

1-benzyl-3-(ethoxycarbonyl)-5-pyrrolidinone

1-t-butyloxycarbonylpyrrole-3-carboxylic acid ethyl ester

1-boc-pyrrolidine-3-carboxylic acid

Downstream raw materials:

1-(4-pyridyl)-3-pyrrolidinecarboxylic acid

Refernces

• 1、 Delaney, Edward J.,Wood, Leigh E.,Klotz, Irving M.. "Poly(ethylenimines) with Alternative (Alkylamino)pyridines as Nucleophilic Catalysts". . p. 799 - 807. Retrieved 2007/10/02.