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Ethyl 1-benzylpyrrolidine-3-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 5747-92-2 Structure
  • Basic information

    1. Product Name: Ethyl 1-benzylpyrrolidine-3-carboxylate
    2. Synonyms: ETHYL 1-BENZYL-PYRROLIDINE-3-CARBOXYLATE;1-BENZYL-PYRROLIDINE-3-CARBOXYLIC ACID ETHYL ESTER;ETHYL 1 -BENZYL-PYRROLIDINE-3-CALATE;3-Pyrrolidinecarboxylic acid, 1-(phenylMethyl)-, ethyl ester
    3. CAS NO:5747-92-2
    4. Molecular Formula: C14H19NO2
    5. Molecular Weight: 233.31
    6. EINECS: N/A
    7. Product Categories: pharmacetical
    8. Mol File: 5747-92-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 308.887 °C at 760 mmHg
    3. Flash Point: 107.442 °C
    4. Appearance: Pale yellow/Liquid
    5. Density: 1.099 g/cm3
    6. Vapor Pressure: 0.001mmHg at 25°C
    7. Refractive Index: 1.542
    8. Storage Temp.: Room temperature.
    9. Solubility: N/A
    10. PKA: 8.43±0.40(Predicted)
    11. CAS DataBase Reference: Ethyl 1-benzylpyrrolidine-3-carboxylate(CAS DataBase Reference)
    12. NIST Chemistry Reference: Ethyl 1-benzylpyrrolidine-3-carboxylate(5747-92-2)
    13. EPA Substance Registry System: Ethyl 1-benzylpyrrolidine-3-carboxylate(5747-92-2)
  • Safety Data

    1. Hazard Codes: Xi,T
    2. Statements: 36/37/38-25
    3. Safety Statements: 26-36/37/39-45
    4. RIDADR: UN 2811 6.1 / PGIII
    5. WGK Germany: 3
    6. RTECS:
    7. HazardClass: IRRITANT
    8. PackingGroup: N/A
    9. Hazardous Substances Data: 5747-92-2(Hazardous Substances Data)

5747-92-2 Usage

Uses

Ethyl 1-benzylpyrrolidine-3-carboxylate

Check Digit Verification of cas no

The CAS Registry Mumber 5747-92-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,4 and 7 respectively; the second part has 2 digits, 9 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 5747-92:
(6*5)+(5*7)+(4*4)+(3*7)+(2*9)+(1*2)=122
122 % 10 = 2
So 5747-92-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H19NO2/c1-2-17-14(16)13-8-9-15(11-13)10-12-6-4-3-5-7-12/h3-7,13H,2,8-11H2,1H3

5747-92-2 Well-known Company Product Price

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  • Alfa Aesar

  • (H64962)  Ethyl 1-benzylpyrrolidine-3-carboxylate, 97%   

  • 5747-92-2

  • 1g

  • 382.0CNY

  • Detail
  • Alfa Aesar

  • (H64962)  Ethyl 1-benzylpyrrolidine-3-carboxylate, 97%   

  • 5747-92-2

  • 5g

  • 1529.0CNY

  • Detail
  • Alfa Aesar

  • (H64962)  Ethyl 1-benzylpyrrolidine-3-carboxylate, 97%   

  • 5747-92-2

  • 25g

  • 6370.0CNY

  • Detail
  • Aldrich

  • (ADE000011)  Ethyl 1-benzyl-pyrrolidine-3-carboxylate  AldrichCPR

  • 5747-92-2

  • ADE000011-1G

  • 1,930.50CNY

  • Detail

5747-92-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 1-Benzylpyrrolidine-3-carboxylate

1.2 Other means of identification

Product number -
Other names Ethyl 1-benzyl-pyrrolidine-3-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5747-92-2 SDS

5747-92-2Relevant articles and documents

Electrochemical Generation of a Nonstabilized Azomethine Ylide: Access to Substituted N-Heterocycles

Kumar, Rakesh,Banerjee, Prabal

, p. 16104 - 16113 (2021/11/18)

Azomethine ylides are fascinating 1,3-dipoles for [3 + 2] cycloaddition reactions toward the construction ofN-heterocycles. Herein, an efficient and environmentally benign electrochemical approach for the generation of a nonstabilized azomethine ylide has been established under metal-free and external oxidant-free conditions. The resulting 1,3-dipole undergoes a [3 + 2] cycloaddition reaction with olefins. This electrosynthetic methodology indulges a straightforward and facile approach for the construction of substituted pyrrolidines.

Photoinduced Nonstabilized Azomethine Ylide Formation for the Preparation of Fluorine Containing Pyrrolidines

Thierry, Thibault,Lebargy, Cyril,Pfund, Emmanuel,Lequeux, Thierry

, p. 5877 - 5885 (2019/05/10)

A mild and reproducible method for the formation of a nonstabilized azomethine ylide was developed by photoinduced reaction catalyzed with eosin Y under green light irradiation. Resulting 1,3-dipole was trapped with fluoroalkenes, fluoroalkylated alkenes,

Photoinduced Nonstabilized Azomethine Ylide Formation for the Preparation of Fluorine Containing Pyrrolidines

Thierry, Thibault,Lebargy, Cyril,Pfund, Emmanuel,Lequeux, Thierry

, (2019/05/08)

A mild and reproducible method for the formation of a nonstabilized azomethine ylide was developed by photoinduced reaction catalyzed with eosin Y under green light irradiation. Resulting 1,3-dipole was trapped with fluoroalkenes, fluoroalkylated alkenes,

Discovery of novel n-substituted prolinamido indazoles as potent rho kinase inhibitors and vasorelaxation agents

Yao, Yangyang,Li, Renze,Liu, Xiaoyu,Yang, Feilong,Yang, Ying,Li, Xiaoyu,Shi, Xiang,Yuan, Tianyi,Fang, Lianhua,Du, Guanhua,Jiao, Xiaozhen,Xie, Ping

, (2017/11/07)

Inhibitors of Rho kinase (ROCK) have potential therapeutic applicability in a wide range of diseases, such as hypertension, stroke, asthma and glaucoma. In a previous article, we described the lead discovery of DL0805, a new ROCK I inhibitor, showing potent inhibitory activity (IC50 6.7 μM). Herein, we present the lead optimization of compound DL0805, resulting in the discovery of 24- and 39-fold more-active analogues 4a (IC50 0.27 μM) and 4b (IC50 0.17 μM), among other active analogues. Moreover, ex-vivo studies demonstrated that 4a and 4b exhibited comparable vasorelaxant activity to the approved drug fasudil in rat aortic rings. The research of a preliminary structure-activity relationship (SAR) indicated that the target compounds containing a β-proline moiety have improved activity against ROCK I relative to analogues bearing an β-proline moiety, and among the series of the derivatives with a β-proline-derived indazole scaffold, the inhibitory activity of the target compounds with a benzyl substituent is superior to those with a benzoyl substituent.

[3+2] Dipolar cycloadditions of an unstabilised azomethine ylide under continuous flow conditions

Grafton, Mark,Mansfield, Andrew C.,Fray, M. Jonathan

scheme or table, p. 1026 - 1029 (2010/04/02)

The [3+2] dipolar cycloaddition reactions of the unstabilised azomethine ylide precursor benzyl(methoxymethyl)(trimethylsilylmethyl)amine with 12 electron-deficient alkenes in the presence of catalytic trifluoroacetic acid are examined under continuous fl

Tris(pentafluorophenyl)borane-catalyzed synthesis of N-benzyl pyrrolidines

Srihari, Pabbaraja,Yaragorla, Srinivasa Rao,Basu, Debjit,Chandrasekhar, Srivari

, p. 2646 - 2648 (2008/02/04)

1,3-Dipolar cycloaddition of in situ generated azomethine ylides to electron deficient olefins catalyzed tris(pentafluorophenyl)borane is described. Georg Thieme Verlag Stuttgart.

QUINOLONE ANTIBACTERIAL AGENTS

-

Page/Page column 69, (2010/02/11)

Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

1-(4-PIPERIDINYL) BENZIMIDAZOLONES AS HISTAMINE H3 ANTAGONISTS

-

Page 71-72, (2010/02/04)

Disclosed are histamine H3 antagonists of the formula (I) wherein R1 is benzimidazolone derivative, M1 and M2 are optionally substituted carbon or nitrogen, R2 includes optionally substituted aryl or heteroaryl, and the remaining variables are as defined

The convenient synthesis of 3-alkyloxycarbonylpyrrolidine derivatives

Dong, Jingchao,Kou, Binbin,Li, Runtao,Cheng, Tieming

, p. 935 - 939 (2007/10/03)

A series of 3-alkyloxycarbonylpyrrolidine derivatives are readily achieved via 1,3-dipolar cycloaddition of α,β-unsaturated esters with nonstabilized azomethine ylides in the presence of samarium diiodide.

Oxadiazoles useful in the treatment of senile dementia

-

, (2008/06/13)

A class of novel oxadiazoles, substituted on one of the ring carbon atoms with a non-aromatic azacyclic or azabicyclic ring, and substituted on the other ring carbon atom with a substituent of low lipophilicity; are potent muscarinic agonists, and have good CNS penetrability. The compounds are therefore useful in the treatment of neurological and mental illnesses.

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