(2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Base Information

Chemical Name:(2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester
CAS No.:625388-57-0
Molecular Formula:C₃₅H₄₀N₄O₅S
Molecular Weight:628.792
Hs Code.:

(2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Synonyms:

Suppliers and Price of (2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

There total 9 articles about (2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3695-77-0
triphenylmethanethiol

: 625388-57-0
(2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 82.5 percent / sodium hydride / dimethylformamide / 0 - 20 °C

2: 78.5 percent / LiBH₄ / tetrahydrofuran / 25 h / 20 °C

3: 94.8 percent / triethylamine / CH₂Cl₂ / 1 h / 0 °C

4: 89.1 percent / dimethylsulfoxide / 5 h / 75 °C

5: 77.1 percent / hydroxylamine hydrochloride; Na₂CO₃ / ethanol; H₂O / 20 h / 60 °C

6: triethylamine / CH₂Cl₂ / 1 h / 0 °C

7: ethanol / 1 h / 20 °C

With lithium borohydride; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(03)00116-8

Reference yield:

: 126408-14-8
methyl (2S,4R)-N-(allyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylate

: 625388-57-0
(2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 93.2 percent / triethylamine / CH₂Cl₂ / 1 h / 0 °C

2: 82.5 percent / sodium hydride / dimethylformamide / 0 - 20 °C

3: 78.5 percent / LiBH₄ / tetrahydrofuran / 25 h / 20 °C

4: 94.8 percent / triethylamine / CH₂Cl₂ / 1 h / 0 °C

5: 89.1 percent / dimethylsulfoxide / 5 h / 75 °C

6: 77.1 percent / hydroxylamine hydrochloride; Na₂CO₃ / ethanol; H₂O / 20 h / 60 °C

7: triethylamine / CH₂Cl₂ / 1 h / 0 °C

8: ethanol / 1 h / 20 °C

With lithium borohydride; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(03)00116-8

Reference yield:

: 126438-17-3
(2S,4R)-1-allyloxycarbonyl-4-methanesulfonyloxy-2-methoxycarbonylpyrrolidine

: 625388-57-0
(2R,4S)-2-{2-[(Z)-Hydroxyimino]-2-[(4-hydroxy-piperidine-1-carbonyl)-amino]-ethyl}-4-tritylsulfanyl-pyrrolidine-1-carboxylic acid allyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 82.5 percent / sodium hydride / dimethylformamide / 0 - 20 °C

2: 78.5 percent / LiBH₄ / tetrahydrofuran / 25 h / 20 °C

3: 94.8 percent / triethylamine / CH₂Cl₂ / 1 h / 0 °C

4: 89.1 percent / dimethylsulfoxide / 5 h / 75 °C

5: 77.1 percent / hydroxylamine hydrochloride; Na₂CO₃ / ethanol; H₂O / 20 h / 60 °C

6: triethylamine / CH₂Cl₂ / 1 h / 0 °C

7: ethanol / 1 h / 20 °C

With lithium borohydride; hydroxylamine hydrochloride; sodium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(03)00116-8