8-methyl(phenyl)phosphino-quinoline

Base Information

• Chemical Name: 8-methyl(phenyl)phosphino-quinoline
• CAS No.: 80127-37-3
• Molecular Formula: C₁₆H₁₄NP
• Molecular Weight: 251.268
• Mol file: 80127-37-3.mol

Synonyms:

Chemical Property of 8-methyl(phenyl)phosphino-quinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-methyl(phenyl)phosphino-quinoline

There total 1 articles about 8-methyl(phenyl)phosphino-quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

quinolin-8-yl trifluoromethanesulfonate (108530-08-1) + diphenyl(methyl)phosphine (1486-28-8) → 8-methyl(phenyl)phosphino-quinoline (80127-37-3,80183-97-7,80183-96-6)

Guidance literature:

palladium diacetate; at 115 ℃; for 72h;

DOI:10.1016/j.tet.2003.10.061

Reference yield: 91.0%

{SP-4-3-(S)}-(+)dichloro{methylphenyl(8-quinolyl)phosphine-P,N}platinum(II)-dichloromethane + 8-methyl(phenyl)phosphino-quinoline (80127-37-3,80183-97-7,80183-96-6) → {SP-5-1-5-{(S),(S)}}-(+)-cis-chlorobis{methylphenyl(8-quinolyl)phosphine-P,N}platinum(II) chloride-dichloromethane

Guidance literature:

In ethanol; Dissolving in EtOH.; filtration, evapn. of solvent, recrystn. (CH2Cl2-Et2O); elem. anal.;

Reference yield: 90.0%

ammonium hexafluorophosphate + (Rc)-di-μ-chloro-bis[1-(1'-dimethylaminoethyl)-2-naphthyl-C,N]dipalladium(ii) + butanone (78-93-3) + 8-methyl(phenyl)phosphino-quinoline (80127-37-3,80183-97-7,80183-96-6) → (-)589-cis-((R)-dimethyl(1-ethyl-α-naphthyl)aminato-C(2)N)((R)-methylphenyl(8-quinolyl)phosphine)palladium(II) hexafluorophosphate (80226-02-4) + (+)589-cis-((R)-dimethyl(1-ethyl-α-naphthyl)aminato-C(2)N)((S)-methylphenyl(8-quinolyl)phosphine)palladium(II) hexafluorophosphate-ethyl methyl ketone solvate

Guidance literature:

In methanol; water; under Ar atm. mixt. (R,S)-methylphenyl(8-quinolyl)phosphine and dichloro-bis((R)-dimethyl(1-ethylα-naphthyl)aminato)dipalladium in methanol stirred until solids dissolved, filtered and excess NH4PF6 in water added; ptt. separated, washed with water, aq. MeOH (1:1), MeOH-Et2O and dried in vacuo, diastereisomers separated by fractional recrystn.: (R,R)-isomer from boiling acetone and (R,S)-isomer from boiling ethyl methyl ketone; elem. anal.;

upstream raw materials:

quinolin-8-yl trifluoromethanesulfonate

diphenyl(methyl)phosphine

Downstream raw materials:

(-)589-cis-((R)-dimethyl(1-ethyl-α-naphthyl)aminato-C(2)N)((R)-methylphenyl(8-quinolyl)phosphine)palladium(II) hexafluorophosphate