1-(2'-O-acetyl-3'-O-benzoyl-5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)uracil pyridinium salt

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Chemical Name:1-(2'-O-acetyl-3'-O-benzoyl-5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)uracil pyridinium salt
CAS No.:124572-51-6
Molecular Formula:C₅H₅N*C₁₉H₂₁N₂O₁₀P
Molecular Weight:547.458
Hs Code.:

Synonyms:

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Chemical Property of 1-(2'-O-acetyl-3'-O-benzoyl-5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)uracil pyridinium salt

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Technology Process of 1-(2'-O-acetyl-3'-O-benzoyl-5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)uracil pyridinium salt

There total 15 articles about 1-(2'-O-acetyl-3'-O-benzoyl-5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)uracil pyridinium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4056-10-4
1,2-O-Isopropyliden-6-O-triphenylmethyl-5-desoxy-α-D-xylo-hexofuran-5-enose

: 124572-51-6
1-(2'-O-acetyl-3'-O-benzoyl-5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)uracil pyridinium salt

Guidance literature:: Multi-step reaction with 14 steps

1: 96 percent / triethylamine / dioxane / 1 h / Ambient temperature

2: acetic acid / dioxane; H₂O / 0.75 h / Heating

3: sodium borohydride / ethanol / 0.25 h / Ambient temperature

4: 95 percent / pyridine / 24 h / 20 °C

5: 97 percent / sodium methylate / methanol / 0.5 h / Ambient temperature

6: 1)dimethyl sulfoxide/acetic anhydride, 2)sodium borohydride / 1)1.5h, 70 deg C, 2)1h, room temperature

7: 85 percent / triethylamine / dioxane / 1 h / 20 °C

8: 89 percent / tin tetrachloride / 1,2-dichloro-ethane / 0.08 h / 20 °C

9: 78 percent / triphenylphosphine/carbon tetrabromide / dimethylformamide / 16 h / 20 °C

10: 100 percent / 4 h / Heating

11: sulfuric acid / acetic acid / 18 h / 20 °C

12: 30 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 16 h / 20 °C

13: bromotrimethylsilane / 1,2-dichloro-ethane / 16 h / 20 °C

14: H₂O / 1 h / 20 °C

With sodium tetrahydroborate; trimethylsilyl bromide; carbon tetrabromide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; sodium methylate; acetic anhydride; tin(IV) chloride; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; In 1,4-dioxane; pyridine; methanol; ethanol; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 7057-09-2
1,2-O-isopropylidene-5-deoxy-α-D-glucofuranose

: 124572-51-6
1-(2'-O-acetyl-3'-O-benzoyl-5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)uracil pyridinium salt

Guidance literature:: Multi-step reaction with 10 steps

1: 89 percent / pyridine / 24 h / 20 °C

2: 1)dimethyl sulfoxide/acetic anhydride, 2)sodium borohydride / 1)1.5h, 70 deg C, 2)1h, room temperature

3: 85 percent / triethylamine / dioxane / 1 h / 20 °C

4: 89 percent / tin tetrachloride / 1,2-dichloro-ethane / 0.08 h / 20 °C

5: 78 percent / triphenylphosphine/carbon tetrabromide / dimethylformamide / 16 h / 20 °C

6: 100 percent / 4 h / Heating

7: sulfuric acid / acetic acid / 18 h / 20 °C

8: 30 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 16 h / 20 °C

9: bromotrimethylsilane / 1,2-dichloro-ethane / 16 h / 20 °C

10: H₂O / 1 h / 20 °C

With pyridine; sodium tetrahydroborate; trimethylsilyl bromide; carbon tetrabromide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; acetic anhydride; tin(IV) chloride; dimethyl sulfoxide; triethylamine; triphenylphosphine; In 1,4-dioxane; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: Benzoic acid (3aR,5R,6S,6aR)-2,2-dimethyl-5-(2-oxo-ethyl)-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester

: 124572-51-6
1-(2'-O-acetyl-3'-O-benzoyl-5',6'-dideoxy-6'-phosphono-β-D-ribo-hexofuranosyl)uracil pyridinium salt

Guidance literature:: Multi-step reaction with 12 steps

1: sodium borohydride / ethanol / 0.25 h / Ambient temperature

2: 95 percent / pyridine / 24 h / 20 °C

3: 97 percent / sodium methylate / methanol / 0.5 h / Ambient temperature

4: 1)dimethyl sulfoxide/acetic anhydride, 2)sodium borohydride / 1)1.5h, 70 deg C, 2)1h, room temperature

5: 85 percent / triethylamine / dioxane / 1 h / 20 °C

6: 89 percent / tin tetrachloride / 1,2-dichloro-ethane / 0.08 h / 20 °C

7: 78 percent / triphenylphosphine/carbon tetrabromide / dimethylformamide / 16 h / 20 °C

8: 100 percent / 4 h / Heating

9: sulfuric acid / acetic acid / 18 h / 20 °C

10: 30 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 16 h / 20 °C

11: bromotrimethylsilane / 1,2-dichloro-ethane / 16 h / 20 °C

12: H₂O / 1 h / 20 °C

With sodium tetrahydroborate; trimethylsilyl bromide; carbon tetrabromide; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; sodium methylate; acetic anhydride; tin(IV) chloride; dimethyl sulfoxide; triethylamine; triphenylphosphine; In 1,4-dioxane; pyridine; methanol; ethanol; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;