4-Nitro-benzoic acid (2S,3S,4S,6S)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

Base Information

Chemical Name:4-Nitro-benzoic acid (2S,3S,4S,6S)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester
CAS No.:76887-90-6
Molecular Formula:C₃₃H₂₇F₃N₂O₁₃S
Molecular Weight:748.644
Hs Code.:

4-Nitro-benzoic acid (2S,3S,4S,6S)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

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Suppliers and Price of 4-Nitro-benzoic acid (2S,3S,4S,6S)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

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Chemical Property of 4-Nitro-benzoic acid (2S,3S,4S,6S)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

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Technology Process of 4-Nitro-benzoic acid (2S,3S,4S,6S)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

There total 28 articles about 4-Nitro-benzoic acid (2S,3S,4S,6S)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52583-22-9
2,3,6-trideoxy-1,4-di-O-p-nitrobenzoyl-3-trifluoroacetamido-L-lyxopyranose

: 76887-88-2,114232-85-8,121715-65-9
(7RS,9RS)-7-acetyl-5,7,9,10-tetrahydroxy-6,7,8,9-tetrahydroanthra<2,3-b>thiophene-4,11-dione

: C₄₈H₄₀F₆N₄O₁₉S

: 76887-90-6,76945-99-8
4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((7R,9R)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; In diethyl ether; dichloromethane; at -15 ℃; for 4h;
DOI:10.1248/cpb.38.1836

Reference yield:

: 114232-90-5
(+/-)-5,7,10-trihydroxy-7-(trimethylsilyl)ethynyl-6,7,8,9-tetrahydroanthra<2,3-b>thiophene-4,11-dione

: 76887-90-6,76945-99-8
4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: HgO, d.H₂SO₄ / tetrahydrofuran / 1.5 h / 70 °C

2: p-TsOH / benzene / 3 h / Heating

3: Br₂, AIBN, H₂O / CHCl₃; CCl₄ / 2 h / 70 °C

4: CF₃CO₂H, H₂O / 1.5 h / 0 °C

5: 1.) benzeneboronic acid, CF₃CO₂H 2.) 2-methylpentane-2,4-diol, acetic acid / 1.) toluene, 0 deg C, 3 h, then RT 13 h 2.) CH₂Cl₂, acetone, RT, 2 h

6: Hg(CN)2, HgBr₂, moecular sieve 3 Aengstroem / CHCl₃ / 0.5 h / Ambient temperature

With 2-methyl-2,4-pentanediol; 2,2'-azobis(isobutyronitrile); 3 A molecular sieve; sulfuric acid; water; bromine; mercury(II) cyanide; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; mercury dibromide; mercury(II) oxide; phenylboronic acid; In tetrahydrofuran; tetrachloromethane; chloroform; benzene;
DOI:10.1016/S0040-4039(00)96434-7

Reference yield:

: 114232-82-5
(+/-)-7-acetyl-5,7,10-trihydroxy-2-trimethylsilyl-6,7,8,9-tetrahydroanthra<2,3-b>thiophene-4,11-dione

: 76887-90-6,76945-99-8
4-Nitro-benzoic acid (2S,3S,4S,6R)-6-((7S,9S)-7-acetyl-5,7,10-trihydroxy-4,11-dioxo-4,6,7,8,9,11-hexahydro-anthra[2,3-b]thiophen-9-yloxy)-2-methyl-4-(2,2,2-trifluoro-acetylamino)-tetrahydro-pyran-3-yl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 98 percent / p-TsOH / benzene / 3 h / Heating

2: n-Bu₄NF / tetrahydrofuran / 0.33 h / Ambient temperature

3: Br₂, AIBN, H₂O / CHCl₃; CCl₄ / 2 h / 70 °C

4: CF₃CO₂H, H₂O / 1.5 h / 0 °C

5: 1.) benzeneboronic acid, CF₃CO₂H 2.) 2-methylpentane-2,4-diol, acetic acid / 1.) toluene, 0 deg C, 3 h, then RT 13 h 2.) CH₂Cl₂, acetone, RT, 2 h

6: Hg(CN)2, HgBr₂, moecular sieve 3 Aengstroem / CHCl₃ / 0.5 h / Ambient temperature

With 2-methyl-2,4-pentanediol; 2,2'-azobis(isobutyronitrile); 3 A molecular sieve; tetrabutyl ammonium fluoride; water; bromine; mercury(II) cyanide; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; mercury dibromide; phenylboronic acid; In tetrahydrofuran; tetrachloromethane; chloroform; benzene;
DOI:10.1016/S0040-4039(00)96434-7