Technology Process of (4R,14R)-4,14-dibenzyl-3,6,9,12,15-pentaoxa-21-azabicyclo<15.3.1>heneicosa-1(21),17,19-triene
There total 6 articles about (4R,14R)-4,14-dibenzyl-3,6,9,12,15-pentaoxa-21-azabicyclo<15.3.1>heneicosa-1(21),17,19-triene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 91 percent / KOH / tetrahydrofuran / 1) 0 deg C, 5 h, 2) room temperature, 12 h
2: 1) NaH / 1) THF, reflux, 1 h, 2a) THF, -78 deg C, 30 min, b) room temperature, 2 d
With
potassium hydroxide; sodium hydride;
In
tetrahydrofuran;
DOI:10.1021/jo00297a031
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 62 percent / NaNO2, HCl
2: 76 percent / LiAlH4
3: 81 percent / Amberlite IRA 400 (OH) / methanol
4: 1) Na / 1) 90 - 100 deg C, 2) 22 h, 100 deg C
5: 1) NaH / 1) THF, reflux, 1 h, 2a) THF, -78 deg C, 30 min, b) room temperature, 2 d
With
hydrogenchloride; lithium aluminium tetrahydride; Amberlite IRA 400; sodium; sodium hydride; sodium nitrite;
In
methanol;
DOI:10.1021/jo00297a031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 76 percent / LiAlH4
2: 81 percent / Amberlite IRA 400 (OH) / methanol
3: 1) Na / 1) 90 - 100 deg C, 2) 22 h, 100 deg C
4: 1) NaH / 1) THF, reflux, 1 h, 2a) THF, -78 deg C, 30 min, b) room temperature, 2 d
With
lithium aluminium tetrahydride; Amberlite IRA 400; sodium; sodium hydride;
In
methanol;
DOI:10.1021/jo00297a031
