(1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol

Base Information

Chemical Name:(1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol
CAS No.:149051-06-9
Molecular Formula:C₃₄H₄₄O₄
Molecular Weight:516.721
Hs Code.:

(1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro<benzofuran-2(3H),1'(2'H)-phenanthrene>-5-ol

Synonyms:

Suppliers and Price of (1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol

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Chemical Property of (1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol

Chemical Property:

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MSDS Files:

Useful:

Technology Process of (1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol

There total 22 articles about (1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 149051-08-1
C₃₆H₄₆O₄S₂

: 149051-06-9
(1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol

Guidance literature:: Raney nickel W-7; In ethanol; for 3h; Heating;

Reference yield:

: 115333-55-6
Methyl (4aR,6S,8aS)-6-(benzyloxy)-3,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethylnaphthalene-1-carboxylate

: 149051-06-9
(1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol

Guidance literature:: Multi-step reaction with 14 steps

1: 88 percent / DIBAL / toluene / 0.5 h / -78 °C

2: Et₃N / CH₂Cl₂ / 0.5 h / -78 °C

3: LiBr / tetrahydrofuran; CH₂Cl₂ / 1 h / -20 °C

4: NaH, n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 1.) 0 deg C, 15 min; 0 deg C, 30 min, 2.) -20 deg C, 15 h

5: 31 percent / SnCl₄ / CH₂Cl₂; H₂O / 2 h / 0 °C

6: NaH / tetrahydrofuran / 1.) reflux, 1 h, 2.) r.t., 1 h

7: 1.) CuI / 1.) ether, -20 deg C, 10 min, 2.) ether, -78 deg C, 0.5 h; -20 deg C, 15 h

8: 94 percent / DIBAL / toluene / 1 h / -78 °C

9: 99 percent / pyridine, DMAP / 0.5 h / 0 °C

10: 1.) n-BuLi, Me₃SnCl, 2.) LiCl / 2.) Pd(dba)2 / 1.) THF, hexane, -50 deg C, 0.5 h; -50 deg C, 3 h, 2.) DMF, 100 deg C, 4 h

11: 71 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / 0.5 h / -20 °C

12: 43 percent / BBr₃ / CH₂Cl₂ / 2.5 h / -78 - -10 °C

13: 62 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

14: 67 percent / Raney nickel W-7 / ethanol / 3 h / Heating

With pyridine; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; dmap; copper(l) iodide; n-butyllithium; boron trifluoride diethyl etherate; trimethyltin(IV)chloride; boron tribromide; tin(IV) chloride; sodium hydride; diisobutylaluminium hydride; triethylamine; lithium chloride; lithium bromide; Raney nickel W-7; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dichloromethane; water; toluene;

Reference yield:

: 172788-43-1
Methyl 5-<(4aR,6S,8aS)-6-(benzyloxy)-3,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethylnaphthalen-1-yl>-3-oxopentanoate

: 149051-06-9
(1'S,2'S,4a'R,4b'S,7'S,8a'S,10a'R)-7'-(Benzoyloxy)-3',4'4a',4b',5',6',7',8',8a',9',10',10a'-dodecahydro-2',4b',7,8',8',10a'-hexamethylspiro-5-ol

Guidance literature:: Multi-step reaction with 10 steps

1: 31 percent / SnCl₄ / CH₂Cl₂; H₂O / 2 h / 0 °C

2: NaH / tetrahydrofuran / 1.) reflux, 1 h, 2.) r.t., 1 h

3: 1.) CuI / 1.) ether, -20 deg C, 10 min, 2.) ether, -78 deg C, 0.5 h; -20 deg C, 15 h

4: 94 percent / DIBAL / toluene / 1 h / -78 °C

5: 99 percent / pyridine, DMAP / 0.5 h / 0 °C

6: 1.) n-BuLi, Me₃SnCl, 2.) LiCl / 2.) Pd(dba)2 / 1.) THF, hexane, -50 deg C, 0.5 h; -50 deg C, 3 h, 2.) DMF, 100 deg C, 4 h

7: 71 percent / CrO₃, 3,5-dimethylpyrazole / CH₂Cl₂ / 0.5 h / -20 °C

8: 43 percent / BBr₃ / CH₂Cl₂ / 2.5 h / -78 - -10 °C

9: 62 percent / BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

10: 67 percent / Raney nickel W-7 / ethanol / 3 h / Heating

With pyridine; 3,5-dimethyl-1H-pyrazole; chromium(VI) oxide; dmap; copper(l) iodide; n-butyllithium; boron trifluoride diethyl etherate; trimethyltin(IV)chloride; boron tribromide; tin(IV) chloride; sodium hydride; diisobutylaluminium hydride; lithium chloride; Raney nickel W-7; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;