EP-2306 free base

Base Information

• Chemical Name: EP-2306 free base
• CAS No.: 479483-55-1
• Molecular Formula: C₂₁H₂₅NO₂
• Molecular Weight: 323.435
• UNII: WE2D2QKP3T
• Nikkaji Number: J1.273.502B
• Wikidata: Q27292584
• ChEMBL ID: CHEMBL154791

Synonyms:EP-2306 free base;WE2D2QKP3T;UNII-WE2D2QKP3T;CHEMBL154791;2H-1,4-Benzoxazin-2-ol, 2-(1,1'-biphenyl)-4-yloctahydro-4-methyl-;479483-55-1;BDBM50213690;Q27292584;2-Biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazin-2-ol;2-(1,1'-Biphenyl-4-yl)-4-methyl-octahydro-4H-1,4-benzoxazine-2-ol

Chemical Property of EP-2306 free base

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 323.188529040
• Heavy Atom Count: 24
• Complexity: 414

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1CC(OC2C1CCCC2)(C3=CC=C(C=C3)C4=CC=CC=C4)O

Technology Process of EP-2306 free base

There total 1 articles about EP-2306 free base which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(methylamino)cyclohexanol (92344-45-1) + 2-Bromo-4'-phenylacetophenone (135-73-9) → 2-biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazin-2-ol (479483-55-1)

Guidance literature:

In acetone; at 20 ℃; for 15h;

DOI:10.1021/jm991039l

Reference yield:

2-biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazin-2-ol (479483-55-1) → 2-biphenyl-4-yl-4-methyl-2-(3-nitrooxy-propoxy)-octahydro-benzo[1,4]oxazine

Guidance literature:

Multi-step reaction with 2 steps

1: HBr(gas) / acetone; diethyl ether / Heating

2: silver nitrate / acetonitrile / 2 h / 80 °C

With hydrogen bromide; silver nitrate; In diethyl ether; acetone; acetonitrile;

DOI:10.1021/jm011062i

Reference yield:

2-biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazin-2-ol (479483-55-1) + 1-bromo-3-propanol (627-18-9) → 2-(4-biphenyl)-2-(3-bromopropoxy)-4-methyloctahydro-1,4-benzoxazine

Guidance literature:

With hydrogen bromide; In diethyl ether; acetone; Heating;

DOI:10.1021/jm011062i

upstream raw materials:

2-(methylamino)cyclohexanol

2-Bromo-4'-phenylacetophenone

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