N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine

Base Information

• Chemical Name: N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine
• CAS No.: 155834-45-0
• Molecular Formula: C₄₅H₆₃N₇O₁₄Si₂
• Molecular Weight: 982.205

Synonyms:

Chemical Property of N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine

There total 3 articles about N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-2,6-dihydropyran (17327-22-9) + N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>-9-<3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>guanine (155834-42-7) → N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine (155834-45-0)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 6.5h; Ambient temperature;

DOI:10.1002/hlca.19940770209

Reference yield:

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane (69304-37-6) → N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine (155834-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / 12 h / Ambient temperature

2: p-TsOH*H₂O / CH₂Cl₂ / 6.5 h / Ambient temperature

With toluene-4-sulfonic acid; In pyridine; dichloromethane;

DOI:10.1002/hlca.19940770209

Reference yield:

N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>guanosine (148144-85-8) → N2-<2-(4-nitrophenyl)ethoxycarbonyl>-O6-<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)guanosine (155834-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / pyridine / 12 h / Ambient temperature

2: p-TsOH*H₂O / CH₂Cl₂ / 6.5 h / Ambient temperature

With toluene-4-sulfonic acid; In pyridine; dichloromethane;

DOI:10.1002/hlca.19940770209

upstream raw materials:

4-methoxy-2,6-dihydropyran

N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>-9-<3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>guanine

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine

Downstream raw materials:

N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4.nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 5'-[2-(2-nitrophenyl)propyl carbonate]

N₂-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O₆-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite) 5'-[2-(2-nitrophenyl)propyl carbonate]

5'-O-(2-dansylethoxycarbonyl)-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶<2-(4-nitrophenyl)ethyl>-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine

N²-{[2-(4-nitrophenyl)ethoxy]carbonyl}-O⁶-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)guanosine

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