2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

Base Information

Chemical Name:2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate
CAS No.:143344-23-4
Molecular Formula:C₆₇H₁₀₄N₇O₁₄PSi₅
Molecular Weight:1403
Hs Code.:

2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

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Chemical Property of 2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

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Technology Process of 2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

There total 6 articles about 2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 143294-21-7
2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosine

: 143294-18-2
triethylammonium salt of 2',5'-bis-O-(tert-butyldimethylsilyl)-uridine 5'-hydrogenphosphonate

: 143294-24-0
2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

: 143344-23-4
2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

Guidance literature:: With pivaloyl chloride; In pyridine;
DOI:10.1021/jo00049a022

Reference yield:

: 129452-86-4
2-<(tert-butyldiphenylsilyloxy)methyl>benzoyl chloride

: 143344-23-4
2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

Guidance literature:: Multi-step reaction with 3 steps

2: 39 percent / pyridine, AgNO₃ / tetrahydrofuran

3: 42 percent / pivaloyl chloride / pyridine

With pyridine; pivaloyl chloride; silver nitrate; In tetrahydrofuran; pyridine;
DOI:10.1021/jo00049a022

Reference yield:

: 143294-16-0
2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>-guanosine

: 143344-23-4
2',5'-bis-O-(tert-butyldimethylsilyl)-2-N-<2-<(tert-butyldiphenylsiloxy)methyl>benzoyl>guanosin-3'-yl 2',3'-bis-O-(tert-butyldimethylsilyl)uridin-5'-yl hydrogen phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 39 percent / pyridine, AgNO₃ / tetrahydrofuran

2: 42 percent / pivaloyl chloride / pyridine

With pyridine; pivaloyl chloride; silver nitrate; In tetrahydrofuran; pyridine;
DOI:10.1021/jo00049a022