N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine

Base Information

• Chemical Name: N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine
• CAS No.: 103818-46-8
• Molecular Formula: C12H17NO2
• Molecular Weight: 207.27
• Mol file: 103818-46-8.mol

Synonyms:N-Methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine;1-(1,3-Benzodioxol-5-yl)-N-methylbutan-2-amine;

Chemical Property of N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.531
• Boiling Point: 284.578 °C at 760 mmHg
• Flash Point: 116.566 °C
• PSA: 30.49000
• Density: 1.079 g/cm³
• LogP: 2.34670

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine

There total 13 articles about N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperonal (120-57-0,30024-74-9) → MBDB (135795-90-3,103818-46-8)

Guidance literature:

Multi-step reaction with 5 steps

1: diethyl ether / 8 h / Heating

2: 91 percent / KHSO₄ / Heating

3: HCOOOH / acetone / 10 h / 40 °C

4: 15percent H₂SO₄ / methanol / 2 h / Heating

5: aluminium amalgam, 25percent aq. NaOH / H₂O; propan-2-ol / 2 h

With sodium hydroxide; potassium hydrogensulfate; Peroxyformic acid; aluminium amalgam; sulfuric acid; In methanol; diethyl ether; water; isopropyl alcohol; acetone;

DOI:10.1021/jm00160a035

Reference yield:

(E)-5-(but-1-en-1-yl)benzo[d][1,3]dioxole (16929-04-7) → MBDB (135795-90-3,103818-46-8)

Guidance literature:

Multi-step reaction with 3 steps

1: HCOOOH / acetone / 10 h / 40 °C

2: 15percent H₂SO₄ / methanol / 2 h / Heating

3: aluminium amalgam, 25percent aq. NaOH / H₂O; propan-2-ol / 2 h

With sodium hydroxide; Peroxyformic acid; aluminium amalgam; sulfuric acid; In methanol; water; isopropyl alcohol; acetone;

DOI:10.1021/jm00160a035

Reference yield:

1-(1,3-benzodioxol-5-yl)butan-1-ol (6890-31-9) → MBDB (135795-90-3,103818-46-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / KHSO₄ / Heating

2: HCOOOH / acetone / 10 h / 40 °C

3: 15percent H₂SO₄ / methanol / 2 h / Heating

4: aluminium amalgam, 25percent aq. NaOH / H₂O; propan-2-ol / 2 h

With sodium hydroxide; potassium hydrogensulfate; Peroxyformic acid; aluminium amalgam; sulfuric acid; In methanol; water; isopropyl alcohol; acetone;

DOI:10.1021/jm00160a035

upstream raw materials:

methylamine hydrochloride

1-(1,3-benzodioxol-5-yl)butan-2-one

piperonal

(E)-5-(but-1-en-1-yl)benzo[d][1,3]dioxole

Refernces

• 1、 Effenberger, Franz,Jaeger, Juergen. "Stereoselective synthesis of (s)-3,4-methylenedioxyamphetamines from (r)-cyanohydrins". . p. 1370 - 1374. Retrieved 2007/10/03.