Cyclopropyl allyl ketone

Base Information

• Chemical Name: Cyclopropyl allyl ketone
• CAS No.: 62316-07-8
• Molecular Formula: C7H10O
• Molecular Weight: 110.156
• Mol file: 62316-07-8.mol

Synonyms:CYCLOPROPYL ALLYL KETONE;

Chemical Property of Cyclopropyl allyl ketone

Chemical Property:

• PSA: 17.07000
• LogP: 1.54160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclopropyl allyl ketone

There total 2 articles about Cyclopropyl allyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopropyltrimethylsilane (930-40-5) + crotonyl chloride (10487-71-5) → 1-cyclopropyl-but-2-en-1-one (62316-07-8)

Guidance literature:

With aluminium trichloride;

DOI:10.1055/s-1976-24180

Reference yield:

→ 1-cyclopropyl-but-2-en-1-one (62316-07-8)

Guidance literature:

With sulfuric acid;

Reference yield:

1-cyclopropyl-but-2-en-1-one (62316-07-8) + dimethyl 2-(pent-4-en-1-yl)malonate → dibenzyl (2S)-2-(2-cyclopropyl-2-oxoethyl)cyclopentane-1,1-dicarboxylate + dibenzyl (2R)-2-(2-cyclopropyl-2-oxoethyl)cyclopentane-1,1-dicarboxylate

Guidance literature:

1-cyclopropyl-but-2-en-1-one; dimethyl 2-(pent-4-en-1-yl)malonate; With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 20 ℃; for 16h; Inert atmosphere;

With 1-[3,5-bis(trifluoromethyl)phenyl]-3-[(1S,2S)-2-(dimethylamino)cyclohexyl]thiourea; In toluene; for 48h; Overall yield = 81 %; Overall yield = 17 mg; enantioselective reaction; Inert atmosphere;

DOI:10.1055/s-0034-1378321

upstream raw materials:

cyclopropyltrimethylsilane

crotonyl chloride