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10487-71-5

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10487-71-5 Usage

General Description

Crotonyl chloride, also known as butenoyl chloride, is a chemical compound with the formula C4H5ClO. It is a colorless to pale yellow liquid with a pungent odor, and it is highly reactive and flammable. Crotonyl chloride is primarily used as a chemical intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the synthesis of fine chemicals and as a reagent in organic chemistry reactions. Crotonyl chloride is a hazardous chemical and must be handled and stored with care due to its corrosive and toxic nature. It should only be used by trained professionals in a well-ventilated environment with appropriate personal protective equipment.

Check Digit Verification of cas no

The CAS Registry Mumber 10487-71-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,8 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 10487-71:
(7*1)+(6*0)+(5*4)+(4*8)+(3*7)+(2*7)+(1*1)=95
95 % 10 = 5
So 10487-71-5 is a valid CAS Registry Number.
InChI:InChI=1/C4H5ClO/c1-2-3-4(5)6/h2-3H,1H3/b3-2-

10487-71-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Crotonyl Chloride

1.2 Other means of identification

Product number -
Other names 2-Butenoyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10487-71-5 SDS

10487-71-5Related news

Low resolution spectra and conformations of CROTONYL CHLORIDE (cas 10487-71-5) and crotyl alcohol08/04/2019

The low resolution spectra of crotonyl chloride and crotyl alcohol have been studied in the microwave R-band region. The spectroscopic constant (B + C) has been evaluated for both molecules. These data have been used to obtain conformational information for these molecules.detailed

Aza-annulation of enaminones with CROTONYL CHLORIDE (cas 10487-71-5) — Formal reversal of regioselectivity08/02/2019

The regiochemistry of aza-annulation of enaminones with α,β-unsaturated acid chlorides bearing hydrogen atoms on the γ-carbon is reversed when triethylamine is used as mediator. When the reaction was carried out at lower temperatures a 3-acyl β,γ-unsaturated compound could be isolated which...detailed

Spectroscopic studies on CROTONYL CHLORIDE (cas 10487-71-5) and dimethyl acryl chloride08/01/2019

Infrared spectra of liquid samples of crotonyl chloride and dimethyl acryl chloride in the region 4000-600 cm−1 have been recorded along with the Raman spectra in the region 4000-100 cm−1. From CNDO/2 results and some band splitting, existence of conformers are inferred. A complete assignment of...detailed

10487-71-5Relevant articles and documents

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Wiberg,Geer

, p. 5827,5831 (1966)

-

New indenyl titanium catalysts for syndiospecific styrene polymerizations

Ready, Thomas E.,Chien, James C.W.,Rausch, Marvin D.

, p. 11 - 27 (1999)

A series of multi-methyl-substituted indenes as well as allylindene, n-propylindene, n-but-1-enylindene, and n-butylindene have been prepared in good yields. The substituted indenes were converted into trimethylsilyl derivatives via reactions of intermediate organolithium complexes with chlorotrimethylsilane. The corresponding titanium complexes were synthesized in excellent yields from reactions of the trimethylsilyl derivatives with TiCl4. The titanium complexes were evaluated as styrene polymerization catalysts in toluene solution when activated by methylaluminoxane. In general, catalytic activities decreased with each additional methyl substituent. Syndiospecificities were very high (90-95%).

-

Richter,Schwarz

, p. 522,524, 525, 526 (1975)

-

Rhodium(III)-Catalyzed Aerobic Oxidative C-H Olefination of Unsaturated Acrylamides with Unactivated Olefins

Logeswaran, Ravichandran,Jeganmohan, Masilamani

, p. 767 - 771 (2021)

A rhodium(III)-catalyzed aerobic oxidative cross-coupling of acrylamides with unactivated alkenes via vinylic C-H activation has been developed. The present cross-coupling reaction was examined with a variety of differently functionalized acrylamides and unactivated olefins. In these reactions, highly valuable amide-functionalized butadienes were prepared in good to excellent yields. This protocol was also compatible with Weinreb amides. A possible reaction mechanism involving the chelation-assisted vinylic C-H activation via a carboxylate-assisted deprotonation pathway is proposed.

-

Ozeki,Kusaka

, p. 1995,1996 (1966)

-

SYNTHESE REGIOSPECIFIQUE D'AMIDO-1 VINYL-2 CYCLOPROPANES A PARTIR DE LITHIENS ALLYLIQUES MONOHALOGENES ET D'AMIDES TERTIAIRES α-ETHYLENIQUIES

Ongoka, Pascal,Mauze, Bernard,Miginiac, Leone

, p. 131 - 140 (1987)

Chloroallyllitium and gem-chloro(methyl)allyllithium readly react, via conjugated addition and cyclisation, with α-ethylenic aliphatic tertiary amides to produce, in a "one-pot" reaction, alkyl-substituted 1-amido-2-vinylcyclopropanes.

-

Fuson,Christ,Whitman

, p. 2450 (1936)

-

Synthesis of thiolactone building blocks as potential precursors for sustainable functional materials

Frank, Daniel,Espeel, Pieter,Claessens, Sven,Mes, Edwin,Du Prez, Filip E.

, p. 6616 - 6625 (2016)

A library of multifunctional monomers from homocysteine thiolactone and thioparaconic acid were synthesized using straightforward chemistry routes. A generic protocol was developed, leading to multi-gram amounts of the targeted compounds and enabling up-scaling experiments for promising compounds in the area of functional coatings. Aspects considered during selection of targets and synthesis pathways included functional diversity, expected physical properties, sustainability and commercial availability of reagents, as well as feasibility to achieve an industrially relevant process. Trends were observed in yield, physical properties and chemical behavior.

Quorum sensing and nf-κb inhibition of synthetic coumaperine derivatives from piper nigrum

Baruch, Yifat,Gopas, Jacob,Kadosh, Yael,Kumar, Rajendran Saravana,Kushmaro, Ariel,Muthuraman, Subramani,Yaniv, Karin

supporting information, (2021/05/28)

Bacterial communication, termed Quorum Sensing (QS), is a promising target for virulence attenuation and the treatment of bacterial infections. Infections cause inflammation, a process regulated by a number of cellular factors, including the transcription Nuclear Factor kappa B (NF-κB); this factor is found to be upregulated in many inflammatory diseases, including those induced by bacterial infection. In this study, we tested 32 synthetic derivatives of coumaperine (CP), a known natural compound found in pepper (Piper nigrum), for Quorum Sensing Inhibition (QSI) and NF-κB inhibitory activities. Of the compounds tested, seven were found to have high QSI activity, three inhibited bacterial growth and five inhibited NF-κB. In addition, some of the CP compounds were active in more than one test. For example, compounds CP-286, CP-215 and CP-158 were not cytotoxic, inhibited NF-κB activation and QS but did not show antibacterial activity. CP-154 inhibited QS, decreased NF-κB activation and inhibited bacterial growth. Our results indicate that these synthetic molecules may provide a basis for further development of novel therapeutic agents against bacterial infections.

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