Ruxolitinib phosphate

Base Information

• Chemical Name: Ruxolitinib phosphate
• CAS No.: 1092939-17-7
• Molecular Formula: C17H18N6.H3PO4
• Molecular Weight: 404.365
• Hs Code.: 29331990
• Mol file: 1092939-17-7.mol

Synonyms:(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile phosphate;

Chemical Property of Ruxolitinib phosphate

Chemical Property:

• PSA: 170.75000
• LogP: 2.53778
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

RuxolitinibPhosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: The phosphate salt of Ruxolitinib (R702000). Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis.
• Clinical Use: Ruxolitinib phosphate is a potent, selective, ATP competitive inhibitor of tyrosine-protein kinases JAK1 and JAK2 which acts by attenuating cytokine signaling and promotes apoptosis. Ruxolitinib was discovered and developed by Incyte, is marketed under the brand name Jakafi,and is approved for the treatment of patients with myelofibrosis (MF), including primary MF, post-polycythemia vera MP, and post-essential thrombocythemia MF. Ruxolitinib is also undergoing clinical evaluation against a wide variety of cancer indications including metastatic prostate cancer, pancreatic cancer, multiple myeloma, leukemia, non-Hodgkin lymphoma, and breast cancer. Additionally, ruxolitinib is being evaluated for the treatment of psoriasis and thrombocytopenia.

Technology Process of Ruxolitinib phosphate

There total 1 articles about Ruxolitinib phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-cyclopentyl-3-oxopropanenitrile (95882-33-0) → ruxolitinib phosphate (1092939-17-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 4-methyl-morpholine / toluene / 0 - 5 °C / Inert atmosphere

2: potassium carbonate; N,N-dimethyl acetamide / water / 13 h

3: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; hydrogen; Walphos SL-W₀₂₂-1 / 2,2,2-trifluoroethanol / 17 h / 20 °C / 7500.75 Torr / Sealed tube

4: trifluoroacetic acid; phosphoric acid

With 4-methyl-morpholine; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; N,N-dimethyl acetamide; phosphoric acid; hydrogen; Walphos SL-W₀₂₂-1; potassium carbonate; trifluoroacetic acid; In 2,2,2-trifluoroethanol; water; toluene;

upstream raw materials:

3-cyclopentyl-3-oxopropanenitrile

Refernces