tert-butyl 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylcarbamate

Base Information

Chemical Name:tert-butyl 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylcarbamate
CAS No.:873556-45-7
Molecular Formula:C18H26N6O5
Molecular Weight:406.442
Hs Code.:
Mol file:873556-45-7.mol

Synonyms:5'-amino-5'-deoxy-N-[(1,1-dimethylethoxy)carbonyl]-2',3'-O-(1-methylethylidene)-Adenosine;

Suppliers and Price of tert-butyl 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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American Custom Chemicals Corporation
TERT-BUTYL 9-((3AR,4R,6R,6AR)-6-(AMINOMETHYL)-2,2-DIMETHYLTETRAHYDROFURO[3,4-D][1,3]DIOXOL-4-YL)-9H-PURIN-6-YLCARBAMATE 95.00%
5MG
$ 505.27

Total 9 raw suppliers

Chemical Property of tert-butyl 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylcarbamate

Chemical Property:

PSA：135.64000
LogP:2.32280

Purity/Quality:

97% ^*data from raw suppliers

TERT-BUTYL 9-((3AR,4R,6R,6AR)-6-(AMINOMETHYL)-2,2-DIMETHYLTETRAHYDROFURO[3,4-D][1,3]DIOXOL-4-YL)-9H-PURIN-6-YLCARBAMATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylcarbamate

There total 8 articles about tert-butyl 9-((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 873556-44-6
tert-butyl (9-((3aR,4R,6R,6aR)-6-(azidomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

: 873556-45-7
tert-butyl 9-(((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 16h;

Reference yield:

: 34245-48-2
5'-azido-5'-deoxy-2',3'-O-isopropylidene adenosine

: 873556-45-7
tert-butyl 9-(((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran; dimethylformamide / 0.5 h / 20 °C

1.2: 60 percent / tetrahydrofuran; dimethylformamide / 3 h / 20 °C

2.1: H₂ / Pd/C / methanol / 3 h / 1900.13 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja069201e

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 873556-45-7
tert-butyl 9-(((3aR,4R,6R,6aR)-6-(aminomethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / tetrahydrofuran; dimethylformamide / 0.5 h / 20 °C

1.2: 60 percent / tetrahydrofuran; dimethylformamide / 3 h / 20 °C

2.1: H₂ / Pd/C / methanol / 3 h / 1900.13 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ja069201e