8-(Trifluoromethyl)chroman-4-amine

Base Information

Chemical Name:8-(Trifluoromethyl)chroman-4-amine
CAS No.:890839-70-0
Molecular Formula:C₁₀H₁₀F₃NO
Molecular Weight:217.191
Hs Code.:
DSSTox Substance ID:DTXSID80585683
Mol file:890839-70-0.mol

Synonyms:8-(trifluoromethyl)chroman-4-amine;890839-70-0;8-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-amine;SCHEMBL3322149;DTXSID80585683;SZKIIVYBHMLAKJ-UHFFFAOYSA-N;MFCD09026487;8-(Trifluoromethyl)chroman-4-ylamine;AKOS005146430;AS-10272;AM20041344;A15887;N13225;8-(trifluoromethyl)-3,4-dihydro-2H-1-benzopyran-4-amine

Suppliers and Price of 8-(Trifluoromethyl)chroman-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
8-(Trifluoromethyl)chroman-4-amine 95+%
1g
$ 455.00

Chemenu
8-(Trifluoromethyl)chroman-4-amine 95%
1g
$ 430.00

American Custom Chemicals Corporation
8-(TRIFLUOROMETHYL)CHROMAN-4-AMINE 95.00%
5MG
$ 502.91

Alichem
8-(Trifluoromethyl)chroman-4-amine
1g
$ 386.88

AK Scientific
8-(Trifluoromethyl)chroman-4-amine
1g
$ 894.00

Total 14 raw suppliers

Chemical Property of 8-(Trifluoromethyl)chroman-4-amine

Chemical Property:

Vapor Pressure:0.0497mmHg at 25°C
Boiling Point:235.6°C at 760 mmHg
Flash Point:96.3°C
PSA：35.25000
Density:1.289g/cm³
LogP:3.18800
Storage Temp.:2-8°C(protect from light)
XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:0
Exact Mass:217.07144843
Heavy Atom Count:15
Complexity:231

Purity/Quality:

97% ^*data from raw suppliers

8-(Trifluoromethyl)chroman-4-amine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COC2=C(C1N)C=CC=C2C(F)(F)F

Technology Process of 8-(Trifluoromethyl)chroman-4-amine

There total 5 articles about 8-(Trifluoromethyl)chroman-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890839-68-6
C₁₁H₁₀F₃NO₂

: 890839-70-0,1228569-07-0
C₁₀H₁₀F₃NO

Guidance literature:: With ammonia; hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 2.5h; under 3102.97 Torr;

Reference yield:

: 890839-62-0
1-(prop-2-yn-1-yloxy)-2-(trifluoromethyl)benzene

: 890839-70-0,1228569-07-0
C₁₀H₁₀F₃NO

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide; silver(I) acetate / acetone / 4 h / Reflux

2: sulfuric acid / 0.5 h / 20 °C

3: pyridine / 24 h / 20 °C

4: palladium 10% on activated carbon; ammonia; hydrogen / methanol / 1 h / 20 °C / 3102.97 Torr

With pyridine; N-chloro-succinimide; sulfuric acid; palladium 10% on activated carbon; ammonia; hydrogen; silver(I) acetate; In methanol; acetone;
DOI:10.1016/j.bmcl.2011.01.056

Reference yield:

: 890839-64-2
1-(3-chloroprop-2-ynyloxy)-2-(trifluoromethyl)benzene

: 890839-70-0,1228569-07-0
C₁₀H₁₀F₃NO

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 0.5 h / 20 °C

2: pyridine / 24 h / 20 °C

3: palladium 10% on activated carbon; ammonia; hydrogen / methanol / 1 h / 20 °C / 3102.97 Torr

With pyridine; sulfuric acid; palladium 10% on activated carbon; ammonia; hydrogen; In methanol;
DOI:10.1016/j.bmcl.2011.01.056