6-Fluoro-1H-indole-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 6-Fluoro-1H-indole-3-carboxylic acid methyl ester
• CAS No.: 649550-97-0
• Molecular Formula: C10H8FNO2
• Molecular Weight: 193.17
• Mol file: 649550-97-0.mol

Synonyms:Rarechem AL BF 0955;

Chemical Property of 6-Fluoro-1H-indole-3-carboxylic acid methyl ester

Chemical Property:

• Melting Point: 194-196 °C
• Boiling Point: 335.3 °C at 760 mmHg
• PKA: 14.82±0.30(Predicted)
• Flash Point: 156.6 °C
• PSA: 42.09000
• Density: 1.341 g/cm³
• LogP: 2.09360
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

Methyl6-Fluoro-1H-indole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Fluoro-1H-indole-3-carboxylic acid methyl ester

There total 4 articles about 6-Fluoro-1H-indole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ methyl 6-fluoroindole-3-carboxylate (649550-97-0)

Guidance literature:

With pyridine; In tetrahydrofuran; at 25 - 30 ℃; for 12h; Cooling with ice;

With potassium hydroxide; at 25 - 65 ℃; for 6h;

Reference yield:

6-fluoro-3-trichloroacetyl-1H-indole + sodium methylate (124-41-4) → methyl 6-fluoroindole-3-carboxylate (649550-97-0)

Guidance literature:

In methanol; at 20 ℃; for 16h;

Reference yield:

methyl 1-(3-fluorophenyl)-1H-1,2,3-triazole-4-carboxylate (1185251-57-3) → methyl 6-fluoroindole-3-carboxylate (649550-97-0) + 2-methoxy-7-fluoro-4(1H)-quinolone (1185251-54-0)

Guidance literature:

at 700 ℃; for 2h; under 2.25023E-05 Torr; Flash vacuum thermolysis (FVT);

DOI:10.1071/CH08515

upstream raw materials:

sodium methylate

methyl 1-(3-fluorophenyl)-1H-1,2,3-triazole-4-carboxylate

Refernces

• 1、 Fulloon, Belinda E.,Wentrup, Curt. "Fluoroquinolones from imidoylketenes and iminopropadienones, RN≤C≤C≤C≤O". experimental part. p. 115 - 120. Retrieved 2009/08/15.