N-(2-Hydroxyethyl)azetidine

Base Information

• Chemical Name: N-(2-Hydroxyethyl)azetidine
• CAS No.: 67896-18-8
• Molecular Formula: C5H11NO
• Molecular Weight: 101.14694
• Hs Code.: 2933998090
• Mol file: 67896-18-8.mol

Synonyms:1-Azetidineethanol;

Chemical Property of N-(2-Hydroxyethyl)azetidine

Chemical Property:

• Boiling Point: 164.1±13.0 °C(Predicted)
• PKA: 14.74±0.10(Predicted)
• PSA: 23.47000
• Density: 1.041±0.06 g/cm3(Predicted)
• LogP: -0.37770
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(Azetidin-1-yl)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Azetidin-1-yl)ethanol is used to prepare novel proline and morpholine derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase type 1 (11-β-hsd-1) for treatment of diabetes and obesity. It is also used in the synthesis of antitumor dibenzonaphthyridine derivatives.

Technology Process of N-(2-Hydroxyethyl)azetidine

There total 2 articles about N-(2-Hydroxyethyl)azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(azetidin-1-yl)-2-oxoethyl acetate (1313410-39-7) → 2-(azetidin-1-yl)ethanol (67896-18-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.75h;

Reference yield: 10.0%

azetidine (503-29-7) + 2-bromoethanol (540-51-2) → 2-(azetidin-1-yl)ethanol (67896-18-8)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃;

DOI:10.1021/acs.jmedchem.8b00921

Reference yield:

2-(azetidin-1-yl)ethanol (67896-18-8) + 2-(4-iodophenyl)-4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromene (1352306-13-8) → 1-(2-(4-(4-methyl-6-((tetrahydro-2H-pyran-2-yl)oxy)-3-(3-((tetrahydro-2H-pyran-2-yl)oxy)phenyl)-2H-chromen-2-yl)phenoxy)ethyl)azetidine

Guidance literature:

With copper(l) iodide; caesium carbonate; at 125 ℃; for 48h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00921

upstream raw materials:

2-(azetidin-1-yl)-2-oxoethyl acetate

azetidine

2-bromoethanol

Refernces

• 1、 -. "FUSED 1,4-DIHYDRODIOXIN DERIVATIVES AS INHIBITORS OF HEAT SHOCK TRANSCRIPTION FACTOR 1". Paragraph 0083. . Retrieved 2015/04/22.
• 2、 -. "ESTROGEN RECEPTOR MODULATORS AND USES THEREOF". Page/Page column 114. . Retrieved 2012/01/05.