4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3,4-dimethoxyphenethyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: 4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3,4-dimethoxyphenethyl)-1H-1,2,3-triazole
• CAS No.: 1335128-21-6
• Molecular Formula: C₁₉H₂₀ClN₃O₃
• Molecular Weight: 373.839
• Mol file: 1335128-21-6.mol

Synonyms:

Chemical Property of 4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3,4-dimethoxyphenethyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3,4-dimethoxyphenethyl)-1H-1,2,3-triazole

There total 8 articles about 4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3,4-dimethoxyphenethyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-azidoethyl)-1,2-dimethoxybenzene (864528-55-2) + 1-(4-chlorophenyl)prop-2-yn-1-ol (29805-11-6) → 4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3,4-dimethoxyphenethyl)-1H-1,2,3-triazole (1335128-21-6)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; at 30 ℃; for 2h; regioselective reaction;

DOI:10.1111/j.1747-0285.2011.01093.x

Reference yield:

vanillin (121-33-5,8014-42-4) → 4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3,4-dimethoxyphenethyl)-1H-1,2,3-triazole (1335128-21-6)

Guidance literature:

Multi-step reaction with 6 steps

1: piperidine / toluene / Reflux

2: cetyltrimethylammonim bromide; sodium hydroxide / dichloromethane / 80 °C

3: sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydroxide / 20 °C

4: triethylamine / dichloromethane / 2 h / 20 °C

5: sodium azide / N,N-dimethyl-formamide / 20 °C

6: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water / 2 h / 30 °C

With piperidine; sodium tetrahydroborate; sodium azide; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; dihydrogen peroxide; cetyltrimethylammonim bromide; sodium L-ascorbate; triethylamine; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; toluene; 1: Knoevenagel condensation / 6: Huisgen cyclooaddition;

DOI:10.1111/j.1747-0285.2011.01093.x

Reference yield:

3,4-dimethoxystyrene (6380-23-0) → 4-((4-chlorophenyl)(hydroxyl)methyl)-1-(3,4-dimethoxyphenethyl)-1H-1,2,3-triazole (1335128-21-6)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium tetrahydroborate; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium hydroxide / 20 °C

2: triethylamine / dichloromethane / 2 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 20 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water / 2 h / 30 °C

With sodium tetrahydroborate; sodium azide; copper(ll) sulfate pentahydrate; boron trifluoride diethyl etherate; dihydrogen peroxide; sodium L-ascorbate; triethylamine; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; 4: Huisgen cyclooaddition;

DOI:10.1111/j.1747-0285.2011.01093.x

upstream raw materials:

4-(2-azidoethyl)-1,2-dimethoxybenzene

1-(4-chlorophenyl)prop-2-yn-1-ol

3,4-dimethoxystyrene

3-methoxy-4-hydroxystyrene

Refernces