2-Methoxy-4-vinylphenol

Base Information

• Chemical Name: 2-Methoxy-4-vinylphenol
• CAS No.: 7786-61-0
• Molecular Formula: C9H10O2
• Molecular Weight: 150.177
• Hs Code.: 29095000
• European Community (EC) Number: 232-101-2
• UNII: DA069CTH0O
• DSSTox Substance ID: DTXSID7052529
• Nikkaji Number: J134.783G
• Wikipedia: 2-Methoxy-4-vinylphenol
• Wikidata: Q4596898
• Metabolomics Workbench ID: 42489
• ChEMBL ID: CHEMBL1232595
• Mol file: 7786-61-0.mol

Synonyms:4-hydroxy-3-methoxystyrene;4-vinylguaiacol

Chemical Property of 2-Methoxy-4-vinylphenol

Chemical Property:

• Appearance/Colour: Colorless to slightly yellow liquid
• Vapor Pressure: 0.0188mmHg at 25°C
• Melting Point: 25-29 °C
• Refractive Index: n20/D 1.582(lit.)
• Boiling Point: 244.958 °C at 760 mmHg
• PKA: 10.00±0.31(Predicted)
• Flash Point: 111.343 °C
• PSA: 29.46000
• Density: 1.09 g/cm³
• LogP: 2.04380
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig
• Water Solubility.: Miscible with water.
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 150.068079557
• Heavy Atom Count: 11
• Complexity: 134

Purity/Quality:

99% ^*data from raw suppliers

p-Vinylguaiacol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C=C)O
• Uses: p-Vinylguaiacol is an aromatic substance and one of the compounds responsible for the natural aroma of buckwheat. It is also one of the major pyrolytic products of (E)-N-[(4-hydroxy-3-methoxy)-phenethyl]-3-[(3-methoxy-4-O-β-D-glucopyranosyloxy) phenyl] acrylamide; a new gycloside in tobacco.

Technology Process of 2-Methoxy-4-vinylphenol

There total 44 articles about 2-Methoxy-4-vinylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) → 3-methoxy-4-hydroxystyrene (7786-61-0,31853-85-7)

Guidance literature:

With phosphate buffer; Catharanthus roseus; at 25 ℃; for 72h; pH=6.0;

DOI:10.1248/cpb.49.639

Reference yield: 98.0%

3-(4-hydroxy-3-methoxyphenyl)acrylic acid (1135-24-6,537-98-4) → 3-methoxy-4-hydroxystyrene (7786-61-0,31853-85-7)

Guidance literature:

With ferulic acid decarboxylase from Enterobacter sp; In aq. phosphate buffer; at 30 ℃; for 19h; pH=7; Sealed tube; Enzymatic reaction;

DOI:10.1021/acs.orglett.8b02058

Reference yield: 95.0%

4-acetoxy-3-methoxyvinylbenzene (46316-15-8) → 3-methoxy-4-hydroxystyrene (7786-61-0,31853-85-7)

Guidance literature:

With cucumber juice; at 30 - 35 ℃; for 6h; Inert atmosphere; Green chemistry;

DOI:10.1039/c6ra01760f

upstream raw materials:

(E)-3-(4-hydroxy-3-methoxyphenyl)acrylic acid

4,4-(ethane-1,1-diyl)bis(2-methoxyphenol)

methyl magnesium iodide

diethyl ether

Downstream raw materials:

4-benzoyloxy-3-methoxy-styrene

vanillin

4-acetoxy-3-methoxyvinylbenzene

4-Ethylguaiacol

Refernces

• 1、 Cardona-G, Wilson,Hernández, Cristian,Herrera-R, Angie,Moreno, Gustavo. "New hybrids based on curcumin and resveratrol: Synthesis, cytotoxicity and antiproliferative activity against colorectal cancer cells". . . Retrieved 2021/05/26.
• 2、 Avenda?o Villarreal, Jesus Alberto,Delolo, Fábio Godoy,Granato, Artur Vicari,Gusevskaya, Elena Vitalievna,dos Santos, Eduardo Nicolau. "The first one-pot metathesis-hydroformylation procedure: a straight synthesis of 2-arylpropanals from renewable 1-propenylbenzenes". . p. 8007 - 8013. Retrieved 2021/12/27.