(S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride

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Chemical Name:(S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride
CAS No.:138875-65-7
Molecular Formula:C₂₈H₃₅F₂N₇O₄*2ClH
Molecular Weight:644.549
Hs Code.:

(S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride

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Chemical Property of (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride

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Technology Process of (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride

There total 10 articles about (S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119860-38-7
(R,S)-α-benzyloxycarbonylamino-3-(4-nitrophenyl)propanal

: 138875-65-7,138920-87-3
(S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 11 steps

1: 1) activated Zn powder, I₂ / 1) THF, rt, ultrasonication, 2) THF, 35 min, ultrasonication

2: NH₃ / diethyl ether / -78 deg C to rt

3: BH₃*Me₂S / tetrahydrofuran / Heating

4: Et₃N / tetrahydrofuran / 0 °C

5: SnCl₂ / ethanol / Heating

7: H₂ / Pd/C / ethanol

8: iBuOCOCl, NMM / MeCN, -20 deg C

9: TFA / 0 °C

10: tetrahydrofuran / 40 °C

11: 1) Pd/C, 3 Angstroem molecular sieves, AcOH, 2) H₂, Pd/C, AcOH, HCl / 1) CH₂Cl₂, 2) iPrOH

With 4-methyl-morpholine; hydrogenchloride; palladium on activated charcoal; dimethylsulfide borane complex; 3 A molecular sieve; ammonia; hydrogen; iodine; acetic acid; triethylamine; trifluoroacetic acid; tin(ll) chloride; zinc; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol;
DOI:10.1016/0040-4039(91)80491-N

Reference yield:

: 119860-09-2
[4-Amino-3,3-difluoro-2-hydroxy-1-(4-nitro-benzyl)-butyl]-carbamic acid benzyl ester

: 138875-65-7,138920-87-3
(S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N / tetrahydrofuran / 0 °C

2: SnCl₂ / ethanol / Heating

4: H₂ / Pd/C / ethanol

5: iBuOCOCl, NMM / MeCN, -20 deg C

6: TFA / 0 °C

7: tetrahydrofuran / 40 °C

8: 1) Pd/C, 3 Angstroem molecular sieves, AcOH, 2) H₂, Pd/C, AcOH, HCl / 1) CH₂Cl₂, 2) iPrOH

With 4-methyl-morpholine; hydrogenchloride; palladium on activated charcoal; 3 A molecular sieve; hydrogen; acetic acid; triethylamine; trifluoroacetic acid; tin(ll) chloride; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/0040-4039(91)80491-N

Reference yield:

: 119885-17-5
N₁-Acetyl-N₄-benzyloxycarbonyl-2,2-difluoro-3-hydroxy-5-(4-aminophenyl)-1,4-pentanediamine

: 138875-65-7,138920-87-3
(S)-1-((R)-2-Amino-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid [4-acetylamino-3,3-difluoro-1-(4-guanidino-benzyl)-2-oxo-butyl]-amide; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

2: H₂ / Pd/C / ethanol

3: iBuOCOCl, NMM / MeCN, -20 deg C

4: TFA / 0 °C

5: tetrahydrofuran / 40 °C

6: 1) Pd/C, 3 Angstroem molecular sieves, AcOH, 2) H₂, Pd/C, AcOH, HCl / 1) CH₂Cl₂, 2) iPrOH

With 4-methyl-morpholine; hydrogenchloride; palladium on activated charcoal; 3 A molecular sieve; hydrogen; acetic acid; trifluoroacetic acid; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/0040-4039(91)80491-N